(2-AMINO-5-BROMOPYRIDIN-3-YL)METHANOL HYDROBROMIDE

To a stirred solution of (2-aminopyridin-3-yl)methanol (22.1 g, 178 mmol) in AcOH (350 mL) was added bromine (9.0 mL, 178 mol) drop wise at rt over 1 hour. The reaction mixture was stirred at rt overnight, then filtered. The filter cake was washed with MTBE (50 mL) and dried in vacuo at 60 °C for 2 hours to give the title compound as a yellow solid (37.9 g, 75percent). MS (ESI, pos. ion) m/z: 203.0 (M-80 +1).The compound (2-aminopyridin-3-yl) methanol (22.1 g, 178 mmol)Was dissolved in AcOH (350 mL)Then at room temperature, to the reaction mixture was added dropwise bromine (9. OmL, 178mol), The reaction mixture was stirred overnight at room temperature. The reaction mixture was suction filtered, the filter cake was washed with MTABE (50 mL) and dried under vacuum at 60 ° C to give the title compound as a yellow solid (37.9 g, 75percent).

Molecular Weight:283.95
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:283.89829
Monoisotopic Mass:281.90034
Topological Polar Surface Area:59.1
Heavy Atom Count:11
Complexity:112
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes