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3-Amino-4-chlorophenol

3-Amino-4-chlorophenol structure

CAS No:
16026-77-0
Formula:
C6H6ClNO
Chemical Name:
3-Amino-4-chlorophenol
Synonyms:
3-AMINO-4-CHLOROPHENOL97;3-Amino-4-chlorophenol;3-AMino-4-chlorophenol;3-Amino-4-chlorophenol 97%
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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3-Amino-4-chlorophenol Basic Attributes

Molecular Weight：

143.57

Exact Mass：

143.01400

DSSTox ID：

DTXSID80408020

HScode：

2922299090

Characteristics

PSA：

46.2

XLogP3：

1.9

Appearance：

Pale orange to brown Powder

Density：

1.406±0.06 g/cm3(Predicted)

Melting Point：

151-154 °C(lit.)

Boiling Point：

282.8±20.0 °C(Predicted)

Flash Point：

124.8ºC

Refractive Index：

1.65

Water Solubility：

Slightly soluble in water.

Vapor Pressure：

0.00192mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

36/37/38

safety instructions：

26-36

Marks：

Precautionary statement(s)：

P261-P305 + P351 + P338

Hazard Statements：

H315-H319-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

3-Amino-4-chlorophenol Use and Manufacturing

4-Chloro-3-nitrophenol (1 g, 5.76 mmol) and NHStep 1. 3-amino-4-chlorophenol [0227] A 100-mL round bottomed flask equipped with a magnetic stir bar was charged with 4- chloro-3-nitrophenol (6.0 g, 34.6 mmol) and acetic acid (60 mL). Iron powder (325 mesh) (19.31 g, 346 mmol) was added, and the mixture was heated at 100 °C for 30 min. The mixture was cooled to room temperature and diluted with water (40 mL). The mixture was then filtered through a pad of Celite and rinsed with water. The filtrate was then extracted with ethyl acetate, and the combined extracts were concentrated under reduced pressure. Heptane (ca. 100 mL) was added to the filtrate and then removed under reduced pressure in order to remove residual acetic acid and water. This was repeated. The residue was dissolved in acetonitrile and concentrated under reduced pressure. The resulting solid was suspended in heptane and concentrated under reduced pressure to afford 3- amino-4-chlorophenol (4.38 g, 88percent) as a pale purple/amber solid. MS (ESI, pos. ion) m/z 144 [M+l].

Computed Properties

Molecular Weight:143.57
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:143.0137915
Monoisotopic Mass:143.0137915
Topological Polar Surface Area:46.2
Heavy Atom Count:9
Complexity:99.1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Henan Lihao Chem Plant Limited Contact Supplier

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Trader Supplier of PVC resin,pvc paste resin,melamine

high quality C6H6ClNO 99% transparent liquid KANBEI

CAS No.: 16026-77-0

Grade: Industrial Grade

Content: 99%

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