4,5-Difluoro-2-pyridinamine

36 · 8 g (0 · 28 mol) of 2-[(Aminooxy)sulfonyl]-l, 3, 5-trimethylbenzene was added to a solution of 4, 5- difluoropyridin-2-amine (47-3; 0.1 g, 0.000769 mol) in dichloromethane (10 mL). The reaction mixture was stirred for 20 min. A precipitate formed and it was filtered and dried under vacuum to afford the title compound. 1H NMR (400 MHz, DMSO) delta 8.91 (bs, 2 H), 8.07-8.04 (m, 1 H), 7.11-7.05 (m, 1 H), 6.87 (s, 2 H), 6.71 (s, 2 H), 2.47 (s, 6 H), 2.15 (s, 3 H).N-(4, 5-difluoropyridin-2-yl)-2, 2-dimethylpropanamide (47-2; 0.380 g) in concentrated HC1 was heated at 95 C for 5 h. The reaction mixture was cooled to RT, diluted with ice cold water (20 mL) and basified with 10% aqueous sodium hydroxide solution. The reaction mixture was extracted with ethyl acetate (2 x 50 mL). The combined organic layers were dried over sodium sulphate and concentrated under vacuum to afford the title compound. 1H NMR (400 MHz, DMSO) delta 7.72-7.67 (m, 1 H), 6.59-6.55 (m, 1 H), 6.48 (bs, 2 H).

Molecular Weight:130.10
XLogP3:0.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:130.03425446
Monoisotopic Mass:130.03425446
Topological Polar Surface Area:38.9
Heavy Atom Count:9
Complexity:99
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes