AnaMorelin hydrochloride
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AnaMorelin hydrochloride
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CAS No:
861998-00-7
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Formula:
C31H42N6O3.HCl
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Chemical Name:
AnaMorelin hydrochloride
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Synonyms:
AnaMorelin hydrochloride;ONO-7643 hydrochloride;RC 1291 hydrochloride;AnaMorelin HCl;(3R)-1-(2-Methylalanyl-D-tryptophyl)-3-(phenylmethyl)-3-piperidinecarboxylic acid trimethylhydrazide monohydrochloride;RC 1291 HCl;Anamorelin (RC-1291) HCl
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CAS No:
Description
Anamorelin hydrochloride is a novel ghrelin receptor agonist with EC50 value of 0.74 nM in the FLIPR assay.
Anamorelin Hydrochloride is the orally bioavailable hydrochloride salt of a synthetic, small-molecule ghrelin mimetic with appetite-stimulating and anabolic activities. Anamorelin binds to and stimulates the growth hormone secretagogue receptor (GHSR) centrally, thereby mimicking the appetite-stimulating and growth hormone-releasing effects of grhelin. Stimulation of GHSR may also reduce the production of the pro-inflammatory cytokines TNF-alpha and interleukin-6, which may play a direct role in cancer-related loss of appetite.
Drug Information
Treatment of anorexia, cachexia or unintended weight loss in adult patients with non-small cell lung cancer (NSCLC)|Treatment of cancer related cachexia
anamorelin
AnaMorelin hydrochloride Use and Manufacturing
Human drugs -> Adlumiz -> EMA Drug Category|All other therapeutic products -> Human pharmacotherapeutic group|Human Drugs -> EU pediatric investigation plans
Computed Properties
Molecular Weight:583.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:582.3085169
Monoisotopic Mass:582.3085169
Topological Polar Surface Area:115
Heavy Atom Count:41
Complexity:904
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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