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Apoptolidin

Apoptolidin structure

CAS No:
194874-06-1
Formula:
C58H96O21
Chemical Name:
Apoptolidin
Synonyms:
apoptolidin;UNII-SAO6WVQ23I;SAO6WVQ23I;FU-40A;CHEMBL4096158;Apoptolidin A Ready Made Solution;HY-126679;CS-0106791;Q27289111
Categories:
Organic Chemistry > Lactones

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Apoptolidin Basic Attributes

Molecular Weight：

1129.38

Exact Mass：

1128.64441 g/mol

EC Number：

200-664-3

UNII：

SAO6WVQ23I

DSSTox ID：

DTXSID90849586

Characteristics

PSA：

290 Å²

Melting Point：

128-130°

Flash Point：

87℃

Storage Conditions：

-20°C

Specific rotation：

21D -5.2° (c = 1.0 in methanol)

Safety Information

Transport codes：

NA 1993 / PGIII

wgk germany：

Drug Information

MeSH Entry Terms：

apoptolidin

Apoptolidin Use and Manufacturing

Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action.

Computed Properties

Molecular Weight:1129.4
XLogP3:2.7
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:21
Rotatable Bond Count:15
Exact Mass:1128.64441007
Monoisotopic Mass:1128.64441007
Topological Polar Surface Area:290
Heavy Atom Count:79
Complexity:2080
Defined Atom Stereocenter Count:25
Defined Bond Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes