(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol
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(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol
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CAS No:
169274-78-6
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Formula:
C22H29NO2
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Chemical Name:
(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol
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Synonyms:
1-Piperidinepropanol,α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-,(αR,βS)-;1-Piperidinepropanol,α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-,[R-(R*,S*)]-;(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol;Ro 25-6981
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CAS No:
Description
4-[(1R,2S)-1-hydroxy-2-methyl-3-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol is a member of piperidines.
(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol Basic Attributes
455.54
339.47
DTXSID20849493
Characteristics
43.7 Ų
3.66610
1.116±0.06 g/cm3(Predicted)
512.4±45.0 °C(Predicted)
379.4ºC
1.587
Desiccate at RT
2.52E-11mmHg at 25°C
(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol Use and Manufacturing
Potent and selective activity-dependent blocker of NMDA receptors containing the NR2B subunit. IC 50 values are 0.009 and 52 μ M for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Displays neuroprotectant effects in vivo and in vitro .
Computed Properties
Molecular Weight:339.5
XLogP3:4.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:339.219829168
Monoisotopic Mass:339.219829168
Topological Polar Surface Area:43.7
Heavy Atom Count:25
Complexity:366
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol
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