Arzoxifene
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Arzoxifene
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CAS No:
182133-25-1
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Formula:
C28H29NO4S
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Chemical Name:
Arzoxifene
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Synonyms:
Benzo[b]thiophene-6-ol,2-(4-methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-;2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]benzo[b]thiophene-6-ol;Arzoxifene;LY 353381;2-(4-Methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol
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CAS No:
Description
Arzoxifene is a synthetic, aromatic derivative with anti-estrogenic properties. Similar to the agent raloxifene, arzoxifene binds to and interacts with estrogen receptors as a mixed estrogen agonist/antagonist. This agent exhibits greater bioavailability and higher anti-estrogenic potency in the breast than does raloxifene; it exhibits reduced estrogenicity in the uterus compared with either tamoxifen or raloxifene. Arzoxifene may have beneficial effects on bone and the cardiovascular system (NCI04)
Drug Information
Investigated for use/treatment in breast cancer, osteoporosis, and endometrial cancer.|Breast carcinoma, Postmenopausal osteoporosis
Arzoxifene is a selective estrogen receptor modulator (SERM) which antagonizes estrogen in mammary and uterine tissue, but acts as an estrogen receptor agonist in bone tissue. Arzoxifene reduces bone loss and risk of osteoperosis and decreases serum cholesterol.
4'F-DMA
Computed Properties
Molecular Weight:475.6
XLogP3:6.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:475.18172958
Monoisotopic Mass:475.18172958
Topological Polar Surface Area:79.4
Heavy Atom Count:34
Complexity:601
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes