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avosentan

avosentan structure

CAS No:
290815-26-8
Formula:
C23H21N5O5S
Chemical Name:
avosentan
Synonyms:
avosentan;N-[6-Methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-2-pyridinesulfonamide;Ro 67-0565;SPP-301;Avosentan (SPP301);N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide;N-(6-Methoxy-5-(2-methoxyphenoxy)-2-(pyridin-4-yl)-pyrimidin-4-yl)-5-methylpyridine-2-sulfonam;2-Pyridinesulfonamide,N-[6-methoxy-5-(2-methoxyphenoxy)-2-(4-pyridinyl)-4-pyrimidinyl]-5-methyl-

Description

Avosentan(Ro 67-0565; SPP-301) is a potent, selective endothelin receptor(ETA receptor) antagonist.IC50 value:Target: ETA receptor

avosentan Basic Attributes

Molecular Weight：

479.50834

Exact Mass：

479.126343

Characteristics

PSA：

134

XLogP3：

0.87

Density：

1.4±0.1 g/cm3

Boiling Point：

575.5±60.0 °C at 760 mmHg

Flash Point：

301.8±32.9 °C

Refractive Index：

1.621

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

avosentan Use and Manufacturing

Avosentan is a competitive antagonist of Endothelin-1 (ET-1) with a high selectivity for the ETA receptor. Avosentan may be a potential option in the treatment of glaucoma.

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Guide of avosentan

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing

avosentan

SDS

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