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1H-Indazol-6-amine

1H-Indazol-6-amine structure

CAS No:
6967-12-0
Formula:
C7H7N3
Chemical Name:
1H-Indazol-6-amine
Synonyms:
1H-Indazol-6-amine;1H-Indazole,6-amino-;6-Aminoindazole;6-Amino-1H-indazole;6-Indazolamine;NSC 208700;NSC 68265;1H-Indazol-6-ylamine
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

light brown powder

1H-indazol-6-amine is a member of indazoles.

1H-Indazol-6-amine Basic Attributes

Molecular Weight：

133.15

Exact Mass：

133.15

EC Number：

230-177-1

UNII：

KN72RH56SR

NSC Number：

208700|68265|16240

DSSTox ID：

DTXSID90219962

HScode：

29339980

Characteristics

PSA：

54.7

XLogP3：

1.6

Appearance：

Tan Powder

Density：

1.4±0.1 g/cm3

Melting Point：

207-208 °C

Boiling Point：

376.6°C at 760 mmHg

Flash Point：

99.2±9.8 °C

Refractive Index：

1.780

Water Solubility：

18.2 [ug/mL]

Safety Information

wgk germany：

hazard class code：

22-36/37/38

safety instructions：

RTECS Number：

NK7712000

Marks：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

6-aminoindazole

1H-Indazol-6-amine Use and Manufacturing

A mixture of 6-nitro-1H-indazole (25 g, 0.153 mmol, commercially available) and 10percent Pd/C (2.0 g) in MeOH was stirred under HGeneral procedure: To a solution of corresponding nitrobenzene (1 equiv) in methanol (20 mL) was added Pd/C (10percent), and the mixture was stirred at room temperature under H2 overnight. The mixture was filtered, and the filtrate was concentrated to afford the desired products 24 and 25. 6.1.11.1 Β24-1(1.5 g, 9.2 mmol) was dissolved in methanol (20 mL), Pd / C (150 mg) was added under nitrogen, replaced twice with hydrogen, Under normal pressure and pressure under hydrogen protection for 12 hours, diatomaceous earth filter, the filtrate was concentrated under reduced pressure yellow solid (l.lg, 92percent).General procedure: To a sealed tube containing the nitro compound (0.6 mmol) and 2 mL ethanol were added 2.6–6.0 mmol of NH

Computed Properties

Molecular Weight:133.15
XLogP3:1.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Exact Mass:133.063997236
Monoisotopic Mass:133.063997236
Topological Polar Surface Area:54.7
Heavy Atom Count:10
Complexity:126
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 1H-Indazol-6-amine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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5 YRS

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CAS No.: 6967-12-0

Content: 99.00%

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Zison Pharmaceutical (Shandong)Co.,Ltd. Contact Supplier

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6-Amino-1H-indazole 6967-12-0

CAS No.: 6967-12-0

Grade: Pharmaceutical Grade

Content: 99%

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