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Midodrine hydrochloride

Midodrine hydrochloride structure

CAS No:
43218-56-0
Formula:
C12H18N2O4.ClH
Chemical Name:
Midodrine hydrochloride
Synonyms:
Acetamide,2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-,hydrochloride (1:1);Acetamide,2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-,monohydrochloride;Acetamide,2-amino-N-(β-hydroxy-2,5-dimethoxyphenethyl)-,hydrochloride;Midodrine hydrochloride;TS 701;St 1085;Gutron;(±)-Midodrine hydrochloride;(±)-Midodrin hydrochloride;ProAmatine;Hipertan;Alphamine;A 4020 Linz;Amatine;St. Peter 224;Midamine;Metligene;2-Amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide hydrochloride;3092-17-9
Categories:
Organic Chemistry > Amides

Description

Midodrine hydrochloride is an α1-receptor agonist, for the treatment of dysautonomia and orthostatic hypotension.

Midodrine hydrochloride is a hydrochloride resulting from the combination of equimolar amounts of midodrine and hydrogen chloride. Midodrine is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. The hydrochloride salt is used as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine. It has a role as an alpha-adrenergic agonist, a sympathomimetic agent and a vasoconstrictor agent. It contains a midodrine(1+).|An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.

Midodrine hydrochloride Basic Attributes

Molecular Weight：

290.74326

Exact Mass：

290.10300

EC Number：

256-148-3

NSC Number：

758429

DSSTox ID：

DTXSID1047493

Characteristics

PSA：

93.8

XLogP3：

1.70530

Density：

1.371 g/cm³

Melting Point：

192-193 °C

Boiling Point：

529.9ºC at 760 mmHg

Flash Point：

274.3ºC

Collision Cross Section：

154 Å² [M+H-H2O]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Precautionary statement(s)：

P264, P270, P301+P310, P321, P330, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P272, P280, P301+P310, P302+P352, P321, P330, P333+P313, P363, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Compounds that bind to and activate ADRENERGIC ALPHA-1 RECEPTORS. (See all compounds classified as Adrenergic alpha-1 Receptor Agonists.)|Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)|Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

MeSH Entry Terms：

Amatine

Midodrine hydrochloride Use and Manufacturing

Uses

A phenylalkanolamine derivative which has been found to be effective in treating hypertensive conditions due to their long lasting blood pressure increasing effects.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:290.74
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:290.1033348
Monoisotopic Mass:290.1033348
Topological Polar Surface Area:93.8
Heavy Atom Count:19
Complexity:263
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes