2-AMINO-5-IODOBENZOTRIFLUORIDE

In the preparation method of the trifluoromethyl aromatic amine of the present embodiment, the aromatic amine is p-iodoaniline, and other reactions and post-treatment processes are the same as in the embodiment 28. Under nitrogen or argon, 4-iodoaniline 0.4 mmol, 0.2mmol, Ir (ppy) 3(2mg) and DMF1 ml was added to the reaction flask, followed by blueLED lights (7W) irradiation until complete conversion of trivalent iodine reagentcompletion of the reaction at room temperature. Add 10 ml of saturated Na 2CO3 Aqueoussolution, and extracted with ethyl acetate three times, the organic layer was washedwith water and once with saturated brine, dried over anhydrous Na 2SO 4The organic layerwas dried. Column chromatography (eluent: petroleum ether 60-90: ethyl acetate = 20: 1-10: 1) to give the product in 60percent yield.General procedure: A 25 mL of Schlenk tube equipped with a magnetic stir bar were charged with aniline (1.2 mmol, 3.0 equiv) or heterocycles (0.8 mmol, 2.0 equiv), K2CO3 (0.8 mmol, 2.0 equiv) and fac-Ir(ppy)3 (2.6 mg, 0.004 mmol, 1 mol percent), under air. The vessel was evacuated and backfilled with Ar (3 times), CF3I stock solution (0.56 mL, 0.71 mmol/mL in 1, 2-chloroethane or 0.36 mL, 1.11 mmol/mL in DMSO, 1.0 equiv), anhydrous 1, 2-dichloroethane (3 mL) were then added. The tube was screw capped and stirred at room temperature under irradiation of blue LEDs (12 W) for 24 hours. The reaction mixture was filtered through a pad of Celite and washed with ethyl acetate (3×5 mL). The filtrate was concentrated. The residue was subjected to column chromatography on silica gel to afford the pure product.N-{4-[3-(4-tert-Butyl-benzyl)-ureidomethyl]-2-trifluoromethyl-6-vinyl- phenyl}-methanesulfonamide EPO 2-Trifluoromethylphenylamine (30mg, 0.21mmol) and ICI (1.1eq, 0.24mmol, 38.97 mg) were added into methylene chloride. The reaction mixture was stirred for 12hrs. The reaction mixture was purified according to step 2 of Example 8 to give the title compound (25.6mg, 42.48percent). IR (NaCl neat, cm

Molecular Weight:287.02
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Exact Mass:286.94188
Monoisotopic Mass:286.94188
Topological Polar Surface Area:26
Heavy Atom Count:12
Complexity:159
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes