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APAMIN

APAMIN structure

CAS No:
24345-16-2
Formula:
C79H131N31O24S4
Chemical Name:
APAMIN
Synonyms:
H-+CYS-ASN-++CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-+CYS-ALA-ARG-ARG-++CYS-GLN-GLN- HIS-NH2;H-CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2;H-CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2 (DISULFIDE BRIDGE: 1-11, 3-15);CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-ARG-CYS-GLN-GLN-HIS-NH2;CYS-ASN-CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS-ALA-ARG-CYS-GLN-GLN-HIS-NH2;[CYS-ASN-(CYS-LYS-ALA-PRO-GLU-THR-ALA-LEU-CYS]CYCL-ALA-ARG-ARG-CYS)CYCL-GLN-GLN-HIS-NH2;CNCKAPETALCARRCQQH-NH2;CNCKAPETALCARRCQQH-NH2 (DISULFIDE BRIDGE: 1-11,3-15)
Categories:
Biochemical Engineering > Enzymes and Coenzymes Drugs

Description

Apamin, an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known to block Ca2+-activated K+ channels and prevent carbon tetrachloride-induced liver fibrosis.

A highly neurotoxic polypeptide from the venom of the honey bee (Apis mellifera). It consists of 18 amino acids with two disulfide bridges and causes hyperexcitability resulting in convulsions and respiratory paralysis.

APAMIN Basic Attributes

Molecular Weight：

2027.34

Exact Mass：

2025.886597

EC Number：

246-182-7

UNII：

X644P85KUR

Characteristics

PSA：

1021.52000

XLogP3：

-14.24

Density：

1.6±0.1 g/cm3

Refractive Index：

1.724

Water Solubility：

0.05 M acetic acid: 5 mg/mL, clear, colorless to faintly yellow

Storage Conditions：

−20°C

Toxicity：

Peritoneal-mouse LD50: 3.8 mg/kg; intravenous-mouse LD50: 4 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and sulfur oxide fumes

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

2811

wgk germany：

safety instructions：

22-24/25

RTECS Number：

CD6899900

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Precautionary statement(s)：

P261-P342 + P311

Hazard Statements：

H334

GHS Classification：

Not Classified

Toxicity

Toxicity class：

most toxic

Drug Information

MeSH Entry Terms：

Apamin

Computed Properties

Molecular Weight:2027.4
XLogP3:-13.4
Hydrogen Bond Donor Count:31
Hydrogen Bond Acceptor Count:33
Rotatable Bond Count:37
Exact Mass:2025.8866089
Monoisotopic Mass:2025.8866089
Topological Polar Surface Area:1020
Heavy Atom Count:138
Complexity:4320
Defined Atom Stereocenter Count:19
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of APAMIN

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Computed Properties
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APAMIN

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