ATPA
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ATPA
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CAS No:
140158-50-5
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Formula:
C10H16N2O4
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Chemical Name:
ATPA
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Synonyms:
(R,S)-ATPA;(RS)-A-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(R,S)-ALPHA-AMINO-3-HYDROXY-5-T-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(RS)-ALPHA-AMINO-3-HYDROXY-5-TERT-BUTYL-4-ISOXAZOLEPROPIONIC ACID;(RS)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOXAZOL-4-YL)PROPANOIC ACID;ATPA;alpha-amino-3-hydroxy-5-tert-butyl-4-isoxazolepropionate;ATP synthase α chain
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CAS No:
Characteristics
102
-1.9
white solid
1.263±0.06 g/cm3(Predicted)
406.8ºC at 760mmHg
199.9ºC
1.529
DMSO: 10 mg/mL
Desiccate at +4°C
2.38E-07mmHg at 25°C
2.15±0.10(Predicted)
Desiccate at +4°C
ATPA Use and Manufacturing
A selective and potent GluR5 kainate receptor agonist (K i = 4.3 nM), inactive at GluR6 (K i > 1 mM) and only weakly active at AMPA receptors (GluR1-4) and the kainate receptors KA-2 and GluR7 (K i values of 6 - 14 μ M). Also available as part of the Kainate Receptor Tocriset™ .
(R,S)-ATPA is a selective and potent GluR5 kainate receptor agonist (1,2). It inhibits GluK2 kainate receptor-JNK3 protein pathway by activating GABA type A receptor in rat after cerebral ischemia-reperfusion injury (3). (R,S)-ATPA is a neuroprotective agent.
Computed Properties
Molecular Weight:228.24
XLogP3:-1.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:228.11100700
Monoisotopic Mass:228.11100700
Topological Polar Surface Area:102
Heavy Atom Count:16
Complexity:354
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes