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Azimilide dihydrochloride

Azimilide dihydrochloride structure

CAS No:
149888-94-8
Formula:
C23H29Cl2N5O3
Chemical Name:
Azimilide dihydrochloride
Synonyms:
2,4-Imidazolidinedione, 1-(((5-(4-chlorophenyl)-2-furanyl)methylene)amino)-3-(4-(4-methyl-1-piperazinyl)butyl)-, dihydrochloride;Azimilide HCl;Azimilide hydrochloride;Unii-6E6vjp68kr;AziMilide Dihydrochloride;NE-10064 Dihydrochloride;1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione dihydrochloride;Azimilide 2HCl

Description

Azimilide 2Hcl(NE-10064 2Hcl) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.IC50 value:Target: in vitro: Azimilide blocked HERG channels at 0.1 and 1 Hz with IC50s of 1.4 microM and 5.2 microM respectively. Azimilide blockade of HERG channels expressed in Xenopus oocytes and I(Kr) in mouse AT-1 cells was decreased under conditions of high [K+]e, whereas block of slowly activating I(Ks

Azimilide dihydrochloride Basic Attributes

Molecular Weight：

494.42

Exact Mass：

529.14100

Color/Form：

white to beige

Characteristics

PSA：

72.6 Å²

Appearance：

white to beige

Density：

1.32g/cm3

Boiling Point：

594.9°C at 760 mmHg

Flash Point：

313.6ºC

Water Solubility：

DMSO: soluble1mg/mL, clear (warmed)

Storage Conditions：

2-8°C

Critical Temperature & Pressure：

2-8°C

Safety Information

Packing level：

Ⅲ

Transport codes：

UN 2811 6.1 / PGIII

wgk germany：

hazard class code：

safety instructions：

Marks：

Storage features：

Store at -20°C

Precautionary statement(s)：

P301 + P310

Hazard Statements：

RIDADR：

UN 2811 6.1 / PGIII

GHS Classification：

|Danger|H301 (97.5%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 40 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

MeSH Entry Terms：

1-(((5-(4-chlorophenyl)-2-furanyl)methylene)amino)-3-(4-(4-methyl-1-piperazinyl)butyl)-2,4-imidazolidinedione dihydrochloride

Azimilide dihydrochloride Use and Manufacturing

Azimilide Dihydrochloride is an oral type III potassium channel blocker agent that blocks both the rapid activating component and the slow activating component of the delayed rectifier potassium current. Both preclinical and clinical studies have demonstrated the efficacy of azimilide and its safety in the treatment of supraventricular and ventricular tachyarrhythmia. Azimilide also is being studied in a worldwide multicenter trial for prevention of sudden cardiac death in patients after myocardial infarction.

Azimilide dihydrochloride may be used in the electrophysiology experiments with human ether-a-go-go-related gene 1a (HERG1a) subunit.

Computed Properties

Molecular Weight:530.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:529.141423
Monoisotopic Mass:529.141423
Topological Polar Surface Area:72.6
Heavy Atom Count:34
Complexity:677
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

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azimilide

CAS No.: 149888-94-8

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Guide of Azimilide dihydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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Azimilide dihydrochloride

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