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MK 1775

MK 1775 structure

CAS No:
955365-80-7
Formula:
C27H32N8O2
Chemical Name:
MK 1775
Synonyms:
3H-Pyrazolo[3,4-d]pyrimidin-3-one,1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-;1,2-Dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-3H-pyrazolo[3,4-d]pyrimidin-3-one;MK 1775;2-Allyl-1-[6-(1-hydroxy-1-methylethyl)pyridin-2-yl]-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one;AZD 1775;WEE 1-1;Adavosertib;1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one;1-[6-(2-Hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one;AZD1775;AZD-1775
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

1-[6-(2-hydroxypropan-2-yl)-2-pyridinyl]-6-[4-(4-methyl-1-piperazinyl)anilino]-2-prop-2-enyl-3-pyrazolo[3,4-d]pyrimidinone is a member of piperazines.|MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.|Adavosertib is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. Adavosertib selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. Unlike normal cells, most p53 deficient or mutated human cancers lack the G1 checkpoint as p53 is the key regulator of the G1 checkpoint and these cells rely on the G2 checkpoint for DNA repair to damaged cells. Annulment of the G2 checkpoint may therefore make p53 deficient tumor cells more vulnerable to antineoplastic agents and enhance their cytotoxic effect.

MK 1775 Basic Attributes

Molecular Weight：

500.59538

Exact Mass：

500.60

UNII：

K2T6HJX3I3

DSSTox ID：

DTXSID30241868

NCI Thesaurus Code：

C91725

Characteristics

PSA：

101

XLogP3：

3.1

Density：

1.292

Boiling Point：

723.804ºC at 760 mmHg

Flash Point：

391.543ºC

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

2-allyl-1-(6-(2-hydroxy-2-propanyl)-2-pyridinyl)-6-((4-(4-methyl-1-piperazinyl)phenyl)amino)-1,2-dihydro-3H-pyrazolo(3,4-d)pyrimidin-3-one

Computed Properties

Molecular Weight:500.6
XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:7
Exact Mass:500.26482229
Monoisotopic Mass:500.26482229
Topological Polar Surface Area:101
Heavy Atom Count:37
Complexity:795
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of MK 1775

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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MK 1775

CAS No.: 955365-80-7

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ROYAL PHARM Contact Supplier

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4 YRS

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AZD1775 CAS No.955365-80-7

CAS No.: 955365-80-7

Grade: Pharmaceutical grade

Content: 99%

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