3,4-bis(2-Methoxyethoxy)benzaldehyde

the 121g (leq) ELTA 1200ml and dimethylformamide (DMF) was stirred clear solution; sequentially added 323g (4eq) 2- chloroethyl methyl ether, 944g (8eq) of anhydrous potassium carbonate and 23.6gTetrabutylammonium bromide; purged with nitrogen three times, Under nitrogen, the reaction was heated to 105~110 ° C 13~14h; the filter cake was rinsed DCM until the filtrate was colorless; the combined filtrate was concentrated under reduced pressure to a fraction distilled off; the residue was added DCM, cooled to room temperature , washed with 3Ν K0H, the DCM phase was separated, washed with water, brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to 45 ° C to give 210g oil ELTB, yield 96.4percentTo a solution of 3, 4-dihydroxybenzaldehyde (10 g, 72.5 mmol) (Aldrich) in DMF (200 mL) was added 2-chloroethyl methyl ether (16.5 mL, 181.2 mmol) (Aldrich), potassium carbonate (50 g, 362.3 mmol) and a catalytic amount of potassium iodide (Aldrich).a) 3, 4-bis (2-methoxyethoxy) benzaldehyde:; To 3, 4-dihydroxy benzaldehyde of the formula Il (25g, 0.1811 mole), potassium carbonate (6Og, 0.4347 mole) in N, N-dimethyl formamide (120ml) was added 2-bromoethylmethyl ether (50.4g, 0.3625 mole). The mixture was stirred at 100a) 3, 4-bis (2-methoxyethoxy) benzaldehyde:; To 3, 4-dihydroxy benzaldehyde of the formula Il (25g, 0.1811 mole), potassium carbonate (6Og, 0.4347 mole) in N, N-dmethyl formamide (120ml) was added 2-bromoethylmethyl ether (50.4g, 0.3625 mole). The mixture was stirred at 100

Molecular Weight:254.28
XLogP3:1.3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:254.11542367
Monoisotopic Mass:254.11542367
Topological Polar Surface Area:54
Heavy Atom Count:18
Complexity:221
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes