BAY 61-3606
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BAY 61-3606
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CAS No:
732983-37-8
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Formula:
C20H18N6O3.2ClH
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Chemical Name:
BAY 61-3606
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Synonyms:
BAY 61-3606;BAY61-3606hydratehydrochloride;2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide;Syk Inhibitor IV, BAY 61-3606: sc-202351hydrochloride;Syk Inhibitor IV, BAY 61-3606 HCl;BAY-61-360;Syk Inhibitor IV, BAY 61-3606
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CAS No:
Description
BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.IC50 value: 7.5 nM (Ki) [1]Target: Sykin vitro: BAY 61-3606 inhibited not only degranulation (IC50 values between 5 and 46 nM) but also lipid mediator and cytokine synthesis in mast cells. BAY 61-3606 was highly efficacious in basophils obtained from healthy human subjects (IC50 = 10 nM) and seems t
2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide is a member of pyrimidines.
Computed Properties
Molecular Weight:390.4
XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:390.14403846
Monoisotopic Mass:390.14403846
Topological Polar Surface Area:117
Heavy Atom Count:29
Complexity:566
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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