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Bazedoxifene acetate

Bazedoxifene acetate structure

CAS No:
198481-33-3
Formula:
C30H34N2O3.C2H4O2
Chemical Name:
Bazedoxifene acetate
Synonyms:
1H-Indol-5-ol,1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-,acetate (1:1);1H-Indol-5-ol,1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-,monoacetate (salt);TSE 424;Bazedoxifene acetate;WAY-TES 424;Viviant;252555-09-2
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

Pale Beige Solid

Bazedoxifene acetate Basic Attributes

Molecular Weight：

530.661

Exact Mass：

530.278076

EC Number：

1592732-453-0

UNII：

J70472UD3D

DSSTox ID：

DTXSID3048657

Characteristics

PSA：

95.2

XLogP3：

6.35980

Appearance：

white to beige

Melting Point：

174-178°

Boiling Point：

694.4°C at 760 mmHg

Flash Point：

373.8ºC

Water Solubility：

DMSO: soluble15mg/mL, clear

Storage Conditions：

-20°C

Vapor Pressure：

6.33E-20mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Precautionary statement(s)：

P201, P202, P273, P281, P308+P313, P391, P405, P501

Hazard Statements：

H361

GHS Classification：

|Warning|H361 (93.75%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P273, P281, P308+P313, P391, P405, and P501|Aggregated GHS information provided by 32 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)|A structurally diverse group of compounds distinguished from ESTROGENS by their ability to bind and activate ESTROGEN RECEPTORS but act as either an agonist or antagonist depending on the tissue type and hormonal milieu. They are classified as either first generation because they demonstrate estrogen agonist properties in the ENDOMETRIUM or second generation based on their patterns of tissue specificity. (Horm Res 1997;48:155-63) (See all compounds classified as Selective Estrogen Receptor Modulators.)

MeSH Entry Terms：

bazedoxifene

Bazedoxifene acetate Use and Manufacturing

Uses

Bazedoxifene Acetate is a nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene Acetate is used as an antiosteoporotic.

Use Classification：

Human drugs -> Rare disease (orphan)|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:530.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:530.27807232
Monoisotopic Mass:530.27807232
Topological Polar Surface Area:95.2
Heavy Atom Count:39
Complexity:654
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Bazedoxifene acetate

CAS No.: 198481-33-3

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CAS No.: 198481-33-3

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