Benzenepropanoicacid,a-hydroxy-b-methoxy-b-phenyl-,(aS)-

500 mg (1.84 mmol) of (RS) -2-hydroxy-3-methoxy-3, 3-diphenylpropanoic acid was dissolved in 8 mL of 2-propanol to prepare , 135 mg (0.92 mmol) of (S) - (+) -1, 2, 3, 4-tetrahydro-1-naphthylamine was added. After stirring for 1 hour under heating reflux, it was cooled to room temperature and stirred for 2 hours. Precipitated crystals were collected by filtration, washed with 2-propanol, and dried under reduced pressure.The same operation as in was carried out using the solvents in Table 1.Step-IV : preparation of S-2-hydroxy-3-methoxy-3, 3-diphenyl propionic acid of the formula -(I) :Into a 3L round bottomed flask compound of formula(IV)from step-III(200g) was added to a mixture methyl tert-butyl ether(1.25L) and acetone(1.5L). Reaction mass was heated to reflux temperature (50-55°C) and S-(-)p-nitro phenyl ethyl amine(61g dissolved in 250ml of MTB) was added slowly during 30minutes at reflux temperature. Reaction mass was maintained at the same temperature for one hour and cooled to 10- 15°C and maintained at the same temperature for 12hours. It was filtered and washed with MTB(500ml) . The wet diastereomeric salt was suspended in a mixture of MTB(500ml) and water(1.5L) and acidified with concentrated hydrochloric acid (30ml). the resulting mixture was stirred for 30minutes and the organic layer was separated. Aqueous layer was extracted with MTB(500ml) and the combined MTB layer was washed with water and distilled completely under vacuum. Reaction mass was brought to 40°C and mixture of MTB (138ml)and n-heptane(322ml) were charged and the cooled to 25-30°CThe crystalline compound of formula -I was filtered and dried at 50-60°C Dry weight : 55g(55percent)Purity by HPLC : 99.97percent(chemical purity)99.98percent(chiral purity)Melting range : 123-125°CL-Proline methyl ester hydrochloride (6.5 kg, 39.25 mol) and anhydrous methanol (3.5 L) were added to a 10 L reaction flask. After stirring well, sodium methoxide (2.12 kg, 39.25 mol) Of anhydrous methanol (5.0L) mixture, after completion of the addition, the reaction was stirred at (15 ~ 30 ° C) for 20 ~ 30min, The mixture was charged to a 300-L reaction vessel, and then a solution of a raw material A (10.68 kg, 39.25 mol) in t-butyl methyl ether (90 L) was also charged to the above reaction vessel to control the temperature at 15-30 ° C ) Was stirred for 20h, Methyl tert-butyl ether (180L) was added to the reaction kettle, and the internal temperature was controlled by stirring at -5 ~ 0 ° C for 30min by circulating cooling. The mixture was filtered and the filtrate was transferred to a 500L reactor.Add hydrochloric acid 3.5L with stirring, purified water 130L, stirred for 3 ~ 5min, allowed to stand for 10 ~ 15min, discard the water layer, The organic layer was dried over anhydrous magnesium sulfate (10 kg), filtered, and the filtrate was concentrated and n-heptane wasadded(37L) crystallization 1.5h.Filtration and drying gave 3.81 kg, yield 35.6percent.HPLC Purity: 99.1percent, Chiral purity: 96.3percent.148.8 g (0.826 mol) of a methanol solution of 30percent concentration sodium methanolate, Was added dropwise to 240 g (0.826 mol) of methanol solution of L-proline methyl ester hydrochloric acid at 57percent concentration at room temperature, And 2.4 l MTB and 225 g (0.826 mol)Of 2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid were added.While dropping 2.4 L of MTB at room temperature, At the same time, 2680 ml of the MTB / methanol mixture was distilled off, The mixture was slowly cooled at room temperature, The crystals (R-2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid × L-proline methyl ester)This solid was washed with 150 ml of MTB.From this, 1.5 l of MTB was distilled off, the filtrate was concentrated, Then 1.0 liter of water was added.Concentrated hydrochloric acid was added at room temperature to adjust the pH to 1.2, After stirring and phase separation, the aqueous phase was separated and extracted with 0.4 l MTB.The combined organic phases were extracted with 0.4 l of water.After MTB was stripped, the residue was dissolved in toluene (65.0 ml) under reflux, And the seed was given to crystallize the product and allowed to cool slowly.The filtrate was suction filtered, washed with toluene, When dried in a vacuum oven, 78.7 g of S-2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid were obtained (yield 35percent based on racemate).To a stirred solution of 2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid (compound VII; 240 gms/ 0.88 moles) in a mixture of tert-butyl methyl ether (1.2 lit) and methanol (1.2 lit) was added (S)-(-)- l-(l-Naphthyl) ethyl amine (82.8 gms/ 0.484 moles). The reaction mass was farther stirred for 1 hour at 25-30°C. The solid was isolated by filtration, washed with tert-butyl methyl ether (500 ml) and dried.The solid was stirred in a mixture of distilled water (1.2 lit) and tert-butyl methyl ether (1.2 lit) and cooled to 10-15°C. The reaction mass was acidified with cone. HC1 and stirred for 30 minutes. The organic phase was separated; aqueous phase was extracted with tert-butyl methyl , ether (1.0 lit). The organic phases were combined together, washed with brine, and concentrated under vacuum at 25-30°C. The residue was stirred in n-Hepatne (720 ml). The solid was isolated by filtration and dried to give 79 g of the title compound (VIII).Efficiency: 32.91 percentPurity by HPLC: 99.5percentChiral purity: 98.1percentAfter dissolving 230 g of diphenyl-2, 3-epoxypropionic acid in 600 mL of methanol at room temperature, 5.7 g of p-toluenesulfonic acid was added and the mixture was stirred at 20-25 ° C for 0.5 h. Reflux, and then dropping 10percent sodium hydroxide 800 mL, after the end of reflux stirring 1.5 h, methanol concentration after adding 90 ml of water, placed in ice bath stirring 0.5 h after filtration, solid and then washed with cold water, 60 ° C Blast dry. The resulting solid was mixed with 60 ml of ethanol and 30 ml of petroleum ether for 1 h, filtered, and dried in vacuo at room temperature to give about 160 g of a white solid. The results of the HPLC test of sodium 2-hydroxy-3-methoxy-3, 3-diphenylpropionate are shown in Table 1 and Fig. 100 gSyntheticSodium 2-hydroxy-3-methoxy-3, 3-diphenylpropionate was addedMethyl tert-butyl ether(MTB, 2000 ml) and methanol (40 ml), and then 56.lg of L-proline methyl ester hydrochloride (0.34 mol) was added and the mixture was stirred at room temperature for 6 h. After standing, the filtrate was filtered, Water, with 6N hydrochloric acid to adjust ρ Η = 1-2. The organic layer was separated and washed with MTB (400 ml). The combined organic layer was washed with 800 ml of water and saturated NaCl. 500 ml and allowed to stand overnight. The solid was filtered, ca. 27 g.500 mg (1.84 mmol) of (RS) -2-hydroxy-3-methoxy-3, 3-diphenylpropanoic acid was dissolved in 8 mL of 2-propanol to prepare , 135 mg (0.92 mmol) of (S) - (+) -1, 2, 3, 4-tetrahydro-1-naphthylamine was added. After stirring for 1 hour under heating reflux, it was cooled to room temperature and stirred for 2 hours. Precipitated crystals were collected by filtration, washed with 2-propanol, and dried under reduced pressure.The same operation as in was carried out using the solvents in Table 1.Step-IV : preparation of S-2-hydroxy-3-methoxy-3, 3-diphenyl propionic acid of the formula -(I) :Into a 3L round bottomed flask compound of formula(IV)from step-III(200g) was added to a mixture methyl tert-butyl ether(1.25L) and acetone(1.5L). Reaction mass was heated to reflux temperature (50-55C) and S-(-)p-nitro phenyl ethyl amine(61g dissolved in 250ml of MTB) was added slowly during 30minutes at reflux temperature. Reaction mass was maintained at the same temperature for one hour and cooled to 10- 15C and maintained at the same temperature for 12hours. It was filtered and washed with MTB(500ml) . The wet diastereomeric salt was suspended in a mixture of MTB(500ml) and water(1.5L) and acidified with concentrated hydrochloric acid (30ml). the resulting mixture was stirred for 30minutes and the organic layer was separated. Aqueous layer was extracted with MTB(500ml) and the combined MTB layer was washed with water and distilled completely under vacuum. Reaction mass was brought to 40C and mixture of MTB (138ml)and n-heptane(322ml) were charged and the cooled to 25-30CThe crystalline compound of formula -I was filtered and dried at 50-60C Dry weight : 55g(55%)Purity by HPLC : 99.97%(chemical purity)99.98%(chiral purity)Melting range : 123-125CL-Proline methyl ester hydrochloride (6.5 kg, 39.25 mol) and anhydrous methanol (3.5 L) were added to a 10 L reaction flask. After stirring well, sodium methoxide (2.12 kg, 39.25 mol) Of anhydrous methanol (5.0L) mixture, after completion of the addition, the reaction was stirred at (15 ~ 30 C) for 20 ~ 30min, The mixture was charged to a 300-L reaction vessel, and then a solution of a raw material A (10.68 kg, 39.25 mol) in t-butyl methyl ether (90 L) was also charged to the above reaction vessel to control the temperature at 15-30 C ) Was stirred for 20h, Methyl tert-butyl ether (180L) was added to the reaction kettle, and the internal temperature was controlled by stirring at -5 ~ 0 C for 30min by circulating cooling. The mixture was filtered and the filtrate was transferred to a 500L reactor.Add hydrochloric acid 3.5L with stirring, purified water 130L, stirred for 3 ~ 5min, allowed to stand for 10 ~ 15min, discard the water layer, The organic layer was dried over anhydrous magnesium sulfate (10 kg), filtered, and the filtrate was concentrated and n-heptane wasadded(37L) crystallization 1.5h.Filtration and drying gave 3.81 kg, yield 35.6%.HPLC Purity: 99.1%, Chiral purity: 96.3%.148.8 g (0.826 mol) of a methanol solution of 30% concentration sodium methanolate, Was added dropwise to 240 g (0.826 mol) of methanol solution of L-proline methyl ester hydrochloric acid at 57% concentration at room temperature, And 2.4 l MTB and 225 g (0.826 mol)Of 2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid were added.While dropping 2.4 L of MTB at room temperature, At the same time, 2680 ml of the MTB / methanol mixture was distilled off, The mixture was slowly cooled at room temperature, The crystals (R-2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid × L-proline methyl ester)This solid was washed with 150 ml of MTB.From this, 1.5 l of MTB was distilled off, the filtrate was concentrated, Then 1.0 liter of water was added.Concentrated hydrochloric acid was added at room temperature to adjust the pH to 1.2, After stirring and phase separation, the aqueous phase was separated and extracted with 0.4 l MTB.The combined organic phases were extracted with 0.4 l of water.After MTB was stripped, the residue was dissolved in toluene (65.0 ml) under reflux, And the seed was given to crystallize the product and allowed to cool slowly.The filtrate was suction filtered, washed with toluene, When dried in a vacuum oven, 78.7 g of S-2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid were obtained (yield 35% based on racemate).To a stirred solution of 2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid (compound VII; 240 gms/ 0.88 moles) in a mixture of tert-butyl methyl ether (1.2 lit) and methanol (1.2 lit) was added (S)-(-)- l-(l-Naphthyl) ethyl amine (82.8 gms/ 0.484 moles). The reaction mass was farther stirred for 1 hour at 25-30C. The solid was isolated by filtration, washed with tert-butyl methyl ether (500 ml) and dried.The solid was stirred in a mixture of distilled water (1.2 lit) and tert-butyl methyl ether (1.2 lit) and cooled to 10-15C. The reaction mass was acidified with cone. HC1 and stirred for 30 minutes. The organic phase was separated; aqueous phase was extracted with tert-butyl methyl , ether (1.0 lit). The organic phases were combined together, washed with brine, and concentrated under vacuum at 25-30C. The residue was stirred in n-Hepatne (720 ml). The solid was isolated by filtration and dried to give 79 g of the title compound (VIII).Efficiency: 32.91 %Purity by HPLC: 99.5%Chiral purity: 98.1%ExampIe-3: Preparation of (S)-2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid compound of formula-7:Methanolic sodium methoxide solution (33 grams) was added to the solution of L-proline methyl ester hydrochloride (30.38 grams) in methanol (28 ml), stirred for 15 minutes at 25-35C then filtered to remove the unwanted solid. The solvent from the reaction mixture was distilled off under reduced pressure at 6O0C. The solution of 2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid compound of formula-6 (50 grams) in methyltertiarybutylether (530 ml) was added to the above residue. The reaction mixture was heated to reflux temperature (55-60C), stirred for 45 minutes and then cooled to 25-35C and further stirred for 30 minutes. The solid separated was filtered off and washed with MTBE. Water (220 ml) was added to the filtrate and pH was adjusted to 1.2 with hydrochloric acid. The aqueous and organic layers were separated and then aqueous layer extracted with MTBE. The total organic layer washed with water and then distilled off the solvent completely under reduced pressure at 60C. Toluene (100 ml) was added to the residue, heated to reflux temperature for 15 minutes then cooled to 25-350C and stirred for 45 minutes. The obtained solid was filtered off and washed with toluene then dried at 50-600C to get the title compound. Yield: 17 grams M.R: 118-1220C. S.O.R: + 26 (C= 0.5; MeOH)Preparation of (S)-2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid R(+)-phenyl ethyl amine (11.12 grams) was added to a solution of 2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid (25 grams) and chloroform (25 ml) at 40 C. and stirred for 30 minutes. The reaction mixture was cooled, and the solid obtained was filtered and washed with chloroform. Ethyl acetate (50 ml) and water (50 ml) was added to the obtained solid and then the reaction mixture was acidified with concentrated hydrochloric acid. The layers were separated and the aqueous layer extracted with ethyl acetate. The solvent from combined organic layer was distilled off completely under reduced pressure at below 60 C. The obtained residue was dissolved in toluene (30 ml) at 60-70 C. and then cooled to 25-30 C. The solid was filtered, washed with toluene and then dried to get the title compound.Yield: 5.5 grams; S.O.R: +28.32Preparation of (S)-2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid compound of formula-7 Methanolic sodium methoxide solution (33 grams) was added to the solution of L-proline methyl ester hydrochloride (30.38 grams) in methanol (28 ml), stirred for 15 minutes at 25-35 C. then filtered to remove the unwanted solid. The solvent from the reaction mixture was distilled off under reduced pressure at 60 C. The solution of 2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid compound of formula-6 (50 grams) in methyltertiarybutylether (530 ml) was added to the above residue. The reaction mixture was heated to reflux temperature (55-60 C.), stirred for 45 minutes and then cooled to 25-35 C. and further stirred for 30 minutes. The solid separated was filtered off and washed with MTBE. Water (220 ml) was added to the filtrate and pH was adjusted to 1.2 with hydrochloric acid. The aqueous and organic layers were separated and then aqueous layer extracted with MTBE. The total organic layer washed with water and then distilled off the solvent completely under reduced pressure at 60 C. Toluene (100 ml) was added to the residue, heated to reflux temperature for 15 minutes then cooled to 25-35 C. and stirred for 45 minutes. The obtained solid was filtered off and washed with toluene then dried at 50-60 C. to get the title compound.Yield: 17 gramsM.R: 118-122 C.S.O.R: +26 (C=0.5; MeOH)Example 9:Preparation of (S)-methyl-2-hydroxy-3-methoxy-3, 3-diphenylpropionate (compound IV from compound VIII; R' = methyl)Stirred 54.4 g (200 mmol) of Take the 3-methoxy-2-((methanesulfonyl) oxy) -3, 3-diphenylpropanoic acid 17.5 (0.05 mol) obtained in the previous step and add it to 100 ml of methanol. Add 10 ml of purified water. At 0 C, slowly add 3.6g (0.09mol) of sodium hydroxide, and control the temperature in an ice-water bath at 0 C for 24 hours. After the reaction is complete, add 200ml of water, adjust the pH == 5 6 with 0.1mol / L hydrochloric acid, and then add acetic acid. Extract 100 ml of ethyl acetate, separate the organic layer, wash the organic layer with 100 ml of saturated brine, concentrate under reduced pressure to dryness, add 26 ml of ethyl acetate and 130 ml of cyclohexane, heat to reflux, cool to 5-10 C, crystallize, filter, and vacuum After drying, 13.2 g of (S) -Take the 3-methoxy-2-((p-toluenesulfonyl) oxy) -3, 3-diphenylpropionic acid 21.3 (0.05mol) obtained in the previous step and add it to 100ml of methanol, add 10ml of purified water, and ice-water bath The temperature was controlled at 0 C, and 3.6 g (0.09mol) of sodium hydroxide was slowly added. The temperature of the ice-water bath was controlled at 0 C for 24 hours. After the reaction was completed, 200 ml of water was added. Extract 100ml of ethyl acetate, separate the organic layer, wash the organic layer with 100ml of saturated brine, concentrate under reduced pressure to dryness, add 30ml of ethyl acetate and 150ml of cyclohexane, heat to reflux, cool to 5-10 C and crystallize.Vacuum dried(S) 12.2g of 2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid, The yield was 89.7%. HPLC test showed that the S configuration content was 84%.Add 3L of N, N-dimethylformamide to a 5L three-necked flask. Add 300 g of the compound of formula II and stir to dissolve; Add 457g of anhydrous potassium carbonate and stir for 10min. Then add 188g of benzyl bromide, Heat to 30 ~ 35 C temperature control stirring reaction for 2h, TLC tracking monitored the disappearance of spots to the compound of formula II, The reaction solution of the compound of the formula IIIa is directly introduced into the next step without treatment.The embodiment of the implementation process see the separation of the process;The specific process includes split 1 and split 2 two parts:Split 1: as in Example 1Split 2: Split 1 (see Example 1) to give 3.81 kg of material, dry methanol (18 L), Methyl tert-butyl ether (18L) was added to a 100L reactor, (R) - (+) - alpha-phenylethylamine (1.51 kg) was dropped at 10 to 30 C, After completion of the dropwise addition, the reaction was stirred for 3 to 4 hours at 10 to 30 C and filtered. The filter cake was washed once with methyl tert-butyl ether (4L) and dried to give 4.75 kg in 124.7% yield.HPLC Purity: 99.83%, Chiral Purity: 99.9%.A solution of 106 g of potassium 2-hydroxy-3-methoxy-3, 3-diphenylpropionate was added to methyl tert-butyl ether (MTB, 2000 ml)And methanol (40 ml)Then 56.1 g of L-proline methyl ester hydrochloride (0.34 mol) was added, Room temperature stirring 6h, Standing, crystallization, filtration, filter cake and filtrate were treated. The filtrate was added with 400 ml of water, and the pH was adjusted to 1 to 2 with 6N hydrochloric acid. The organic layer was separated and extracted with MTB (400 ml). The organic layers were combined, washed with 800 ml of water and saturated NaCl solution. The organic layer was dried over anhydrous sodium sulfate, concentrated, and recrystallized from 80 ml of ethyl acetate and 500 ml of cyclohexane , Put it overnight. And 28.3 g of S-2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid was obtained in a yield of 30.6%. 59.2 g of the cake was R-2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid-L-proline methyl ester salt, Add 200mL of water and 1000mL of ether, 1mol / L sulfuric acid 0.2mL, heated to reflux for 8 hours, Add 5mol / L sulfuric acid 13.5mL, adjust the solution pH = 1 ~ 2, liquid separation, the organic phase, concentrated under reduced pressure, add methanol dissolved 80mL, add water 100mL, dropping 10% potassium hydroxide solution 69ml, a large number of white solid precipitation, Ice bath for 0.5h after the filter, 60 blast drying. The resulting solid was stirred with 60 ml of ethanol and 120 ml of petroleum ether for 1 h, filtered and dried at 60 C with blowing to give 33.2 g of a white solid. The recovered 2-hydroxy-3-methoxy-3, 3-diphenylpropionate was added to methyl tert-butyl ether (MTB, 650 ml) and methanol (130 ml), followed by the addition of 17.6 g of L-proline methyl ester hydrochloride, stirring at room temperature for 6h, after crystallization of static separation, the filtrate by adding 130ml of water, with 6N hydrochloric acid to adjust the pH = 1 ~ 2. The organic layer was separated and extracted with MTB (300 ml). The organic layers were washed with the organic layer and the saturated NaCl solution. The organic layer was dried over anhydrous sodium sulfate and concentrated. The crystals were recrystallized from ethyl acetate and cyclohexane and allowed to stand overnight. A solution of 8.6 g of solid S-2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid in a yield of 9.3% (2-hydroxy-3-methoxy- - diphenylpropionic acid potassium).100g of 2-hydroxyl-3-methoxy-3, 3-sodium diphenyl propionate is added into the methyl tert-butyl ether (MTB, 2000 ml) and methanol (40 ml), and then added the 56.1g L-Proline Methyl Ester hydrochloride (0.34 mol), stirring at room temperature for 6h, standing, crystallization, filtration, the filter cake and the filtrate are treated separately. into the filtrate added 400 ml of water, with 6N hydrochloric acid adjust pH=1~2. The organic layer is separated and the aqueous layer is extracted with MuTB (400 ml), the organic layers are combined, the organic layer is washed with 800 ml of water, saturated NaCl solution, dried over anhydrous sodium sulfate, concentrated, and then re-crystallized from 80 ml of ethyl acetate and 500 ml of cyclohexane, stand still overnight. Filter and then obtained S-2-hydroxyl-3-methoxy-3, 3-diphenylpropionic acid 27.0g, yield 29.2%. Filter cake 61.4g is R-2-hydroxyl-3-methoxy-3, 3-diphenylpropionic acid-L-proline methyl ester salt, into this added 300mL of water and 300mL of methyl t-butyl ether, 0.3 g of p-toluenesulfonic acid monohydrate, heated at reflux for 10 hours, add 6mol / L hydrochloric acid 26mL, solution pH=1 ~ 2, liquid, the organic phase is collected, concentrated under reduced pressure, and dissolved in 80mL of ethanol, add water 100mL, add drops of 10% sodium hydroxide solution 56mL, a large amount of white solid precipitation, the mixture is stirred under ice bath for 0.5h and filtered, dry at 60 C. The resulting solid is stirred with 60 ml of ethanol and 120 ml of petroleum ether for 1 h, filter, dry at 60 C, and then obtained white solid about 33.1g. the recovered 2-hydroxyl-3-methoxy-3, 3-diphenylpropionate is added into methyl tert-butyl ether (MTB, 650 ml) and methanol (130 ml), and then added 18. 6g L-Proline methyl ester hydrochloride, stirring at room temperature for 6h, standing, crystallization, filtration, into the filtrate added 130 ml of water, with 6N hydrochloric acid adjust pH=1~2. Separating the organic layer, the aqueous layer is extracted with MuTB (300 ml), the organic layers are combined, saturated NaCl solution, dried over anhydrous sodium sulfate, concentrated, and then re-crystallized from ethyl acetate and cyclohexane, stand still overnight. Filter solids S-2-hydroxyl-3-methoxy-3, 3-diphenylpropionic acid, approximately 8.4g, yield 9.1% (Based on the first charge of 2-hydroxyl-3-methoxy-3, 3-sodium diphenyl propionate).(S) -2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid L-prolineamide salt was suspended in 300 ml of a mixed solvent of ether: H2O = 1: 1, Suspended in 300 ml of a mixed solvent, and adjusted to pH 2 with 3N HCl aqueous solution.The organic layer was separated, dried, filtered and distilled under reduced pressure to obtain 40 g of the (S) -2-hydroxy-3-methoxy-3, 3-diphenylpropionic acid (yield: 95%) (ee = 100%).

Molecular Weight:272.29
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:272.10485899
Monoisotopic Mass:272.10485899
Topological Polar Surface Area:66.8
Heavy Atom Count:20
Complexity:298
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes