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Triclosan

Triclosan structure

CAS No:
3380-34-5
Formula:
C12H7Cl3O2
Chemical Name:
Triclosan
Synonyms:
Phenol,5-chloro-2-(2,4-dichlorophenoxy)-;5-Chloro-2-(2,4-dichlorophenoxy)phenol;2,4,4′-Trichloro-2′-hydroxydiphenyl ether;Irgasan CH 3565;Irgasan DP 300;2-Hydroxy-2′,4,4′-trichlorodiphenyl ether;2′,4′,4-Trichloro-2-hydroxydiphenyl ether;2,2′-Oxybis(1′,5′-dichlorophenyl-5-chlorophenol);4-Chloro-2-hydroxyphenyl 2,4-dichlorophenyl ether;Triclosan;CH 3565;2′,4,4′-Trichloro-2-hydroxydiphenyl ether;Irgasan;3-Chloro-6-(2,4-dichlorophenoxy)phenol;Irgasan DP 3000;Zilesan UW;THDP;Bacti-Stat soap;Irgasan DP 30;DP 300;Irgasan PE 30;Irgasan PG 60;Irgacide LP 10;Microban Additive B;Ultra-Fresh NM 100;NM 100;Microban B;Irgaguard B 1000;Tinosan AM 100;Tinosan AM 110;Yujiexin;Vinyzene DP 7000;TCCP;2′-Hydroxy-2,4,4′-trichlorodiphenyl ether;Irgasan DP 400;Oletron;Cansan TCH;SterZac;CH 3635;Sapoderm;Gamophen;Aquasept;Sanitized XTX;Irgacare MP;Irgaguard B 1325;Ultra-Fresh NM-V 2;Microban;2,4,4′-Trichloro-2′-hydroxyldiphenyl ether;Microfresh Liquid Formulation 9200-200;Invasan;Invasan DP 300R;Microfresh 9200-200;Anvasan AM 110;Anvasan AM 110 new;2-(2,4-Dichlorophenoxy)-5-chlorophenol;Germicide CA;112099-35-1;88032-08-0;164325-69-3;261921-78-2;1155174-27-8
Categories:
Cosmetic Ingredient > Cosmetic Preservative

Description

Triclosan is an antibacterial and antifungal agent found in consumer products, including soaps, detergents, toys, and surgical cleaning treatments.

Triclosan Basic Attributes

Molecular Weight：

289.54200

Exact Mass：

289.54

EC Number：

222-182-2

HScode：

2909500000

Characteristics

PSA：

29.46000

XLogP3：

Appearance：

white to off-white powder

Density：

1.49 g/cm3

Melting Point：

54-57.3 °C

Boiling Point：

50-54 °C

Flash Point：

162.2ºC

Refractive Index：

1.632

Water Solubility：

In water, 10 mg/L at 20 deg C

Storage Conditions：

Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water. /Residential users/

Vapor Pressure：

4.6X10-6 mm Hg at 20 deg C (est)

Toxicity：

LD50 orl-rat: 3700 mg/kg 26UZAB 6,245,68/70

Safety Information

Packing level：

III

Hazard category：

Transport codes：

UN 3077 9/PG 3

wgk germany：

hazard class code：

R36/38

safety instructions：

S22-S24/25

RTECS Number：

KO1100000

Marks：

Xi; N

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P273-P305 + P351 + P338-P391-P501

Hazard Statements：

H315-H319-H410

Triclosan Use and Manufacturing

Methods of Manufacturing

TCS solutions were prepared of a stock solution for each experiment. The conductivity, measured by a digital conductivity meter (GMH 3430, Greisinger electronic GmbH, Regenstauf, Germany), was adjusted to a desired value by addition of electrolytes. The solution was filled in the reactor and the electrodes were immersed in the system. After taking 2 mL sample (initial TCS concentration) for HPLC, the sonoelectrochemical system run for 15 min and the temperature was adjusted by the thermostat. The energy was measured with an energy monitor (Energy Monitor 3000, Conrad electronics, Hirschau, Germany). After completion of the reaction, another sample was taken directly from the solution and measured by HPLC. The pH measurements were performed at the same temperature with the help of a microprocessor pH-meter (Hanna Instruments Deutschland GmbH, Kehl am Rhein, Germany).General procedure: The enzymatic removal of NP and TCS was performed according to Cabana et al. [25]. The reaction mixture contained EDCs (NP or TCS; 10 ppm), purified MnPs, Na-malonate buffer (50 mmol/L; pH = 4.5), MnSO4 (50 mumol/L), and 0.4 mmol/L H2O2. During NP treatment, 0.5% methanol and 0.075% Tween-80 were added to the reaction mixture to enhance the solubility of NP. The reaction was performed at 30 C with stirring at 150 r/min. For the MnP-mediator system, 0.2 mmol/L MnSO4 was added to the reaction mixture as MnP treatment. To verify that degradation was specifically caused by enzymatic oxidation, a control reaction was conducted using distilled water instead of enzyme solution. Samples were periodically collected to investigate the remaining enzymatic activities and EDC concentration.

Uses

1. Used as bacteriostat and preservative for cosmetic and detergent compositions. Antiseptic, disinfectant.
2. Anticonvulsant

Computed Properties

Molecular Weight:289.5
XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:287.951163
Monoisotopic Mass:287.951163
Topological Polar Surface Area:29.5
Heavy Atom Count:17
Complexity:252
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Acetaminophen

Potassium hydroxide

Ibuprofen

1-Propanol

2,6-Dichlorophenol

N-Vinyl-2-pyrrolidone

Drug Function and Efficacy

Triclosan, as the antibacterial ingredient of Xinshique, is a phenoxyphenol containing multiple chlorines, and its antibacterial spectrum is very broad. The antibacterial effects of its minimum inhibitory concentration (MIC) range of about 10-2 to 10mu;g/ml include: Gram-positive bacteria such as Staphylococcus (including Staphylococcus aureus), Streptococcus, Clostridium, Gram-negative bacteria such as Escherichia coli, Proteus vulgaris, Proteus mirabilis, Salmonella, Shigella, Moraxella, Brucella, Vibrio, Gangka, Actinomyces, Streptococcus, Congo Dermatophilus. For skin fungi (such as dermatophytes, Trichophyton, Microsporum) and molds (Candida), its antibacterial activity is weaker (MIC: 1 to 33mu;g/ml). The bacteria that are ineffective against this product are: Alcaligenes, Mycoplasma, Proteus, Sawbacterium, Pseudomonas aeruginosa, Mycobacterium tuberculosis, Corynebacterium, and Streptococcus hominis. Triclosan has antibacterial activity at the above low concentrations and high titers of bacteria (1mu;g/ml), which may be due to damage to the bacterial cell membrane.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Halometasone/Triclosan Cream
Ingredients	This product is a compound preparation, and its components are as follows: 1 gram of cream contains: Active substance: 0.5 mg of halometasone monohydrate, 10 mg of triclosan. Excipients: lauryl sulfate, propylene glycol, added to 1 gram.
Indication	So far, there are no known incompatibilities or interactions between this product and other drugs.
Specifications	Halometasone monohydrate (0.05%), triclosan (1%)

Halometasone/Triclosan Cream
Indication	So far, no incompatibility or interaction with other drugs is known.
Specifications	Halometasone monohydrate (0.05%), triclosan (1%)

Halometasone/Triclosan Cream
Ingredients	This product is a compound preparation, and its components are: each gram of cream contains 0.5 mg of halometasone monohydrate and 10 mg of triclosan.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Halometasone monohydrate (0.05%), triclosan (1%)

See More Related Drugs

Registered Holders

BASF Grenzach GmbH

Germany
Active
KUMAR ORGANIC PRODUCTS LTD

United States
Active
VIVIMED LABS ALATHUR PRIVATE LTD

United States
Active

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