2-(2,4-Dihydroxyphenyl)-4,6-bis(2,4-dimethylphenyl)-1,3,5-triazine

DryPowder

General procedure: To astirred anhydrous chlorobenzene (15 mL) under dry N2 protectionin a 50mL three-necked flask were added 5 (1.6mmol)and anhydrous AlCl3 (0.32 g, 2.4 mmol), the mixture wasstirred for 0.5 h at 25 °C. Then resorcinol (0.24 g, 2.2 mmol)was added, and the mixture was stirred for 5 h at 85 °C. Aftercooling to room temperature, ice water (10 mL) was addedslowly and then chlorobenzene was evaporated under reducedpressure. The mixture was filtered and washed with water(3 × 10 mL), the filter cake was recrystallized with EtOA togive the corresponding products 8a, 8e 9a-9d.EXAMPLE 4 EXAMPLE 6 In a 5-liter three-necked flask equipped with mechanical stirring, 3 liters of chlorobenzene, 184 grams of cyanuric chloride, 212 grams of m-xylene were added(2 times the amount) and 400 g of aluminum trichloride (3 times the amount); under ice-cooling, 20 ml of concentrated hydrochloric acid (0.2 times) was added, the reaction was stirred for 1 hour, and the temperature was raised to room temperature and 121 g of resorcinol was added ( 1.1 times) and then heated to 90°C for 2 hours. After the reaction was completed, the reaction solution was slowly added to 5 liters of 10percent hydrochloric acid with stirring, and the precipitated solid was filtered and washed with water.Recrystallization yielded 365 g (yield 92percent) of 2, 4-bis(m-xylyl)-6-(1-m-xylenol)-1, 3, 5-triazine product.EXAMPLE 7

Intermediates

500,000 - 1,000,000 lb

Molecular Weight:397.5
XLogP3:5.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:397.17902698
Monoisotopic Mass:397.17902698
Topological Polar Surface Area:79.1
Heavy Atom Count:30
Complexity:527
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes