Maribavir
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Maribavir
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CAS No:
176161-24-3
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Formula:
C15H19Cl2N3O4
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Chemical Name:
Maribavir
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Synonyms:
1H-Benzimidazol-2-amine,5,6-dichloro-N-(1-methylethyl)-1-β-L-ribofuranosyl-;5,6-Dichloro-N-(1-methylethyl)-1-β-L-ribofuranosyl-1H-benzimidazol-2-amine;BW 1263W94;1263W94;Maribavir;GW 257406X
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CAS No:
Description
Maribavir is a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, with an IC50 of 3 nM. Maribavir has potent antiviral activity against HCMV and Epstein-Barr virus (EBV).
Maribavir is an orally available benzimidazole riboside compound with activity against cytomegalovirus (CMV). Maribavir is a selective ATP competitor of viral UL97 kinase, which is involved in viral nuclear maturation events, such as viral DNA assembly and movement of viral capsids from the nucleus of infected cells. Maribavir has activity against strains of CMV that are resistant to standard anti-CMV agents.
Maribavir Basic Attributes
376.24
376.24
PTB4X93HE1
DTXSID60170091
C82254
J - Antiinfectives for systemic use
Characteristics
99.8
2.71
1.67±0.1 g/cm3 (20 ºC 760 Torr)
611.0±65.0 °C(Predicted)
323.3±34.3 °C
1.703
Drug Information
Investigated for use/treatment in viral infection, transplantation (organ or tissue), cytomegalovirus (CMV) retinitis, and retinal disorders (unspecified).|Cytomegaloviral disease|Treatment of cytomegalovirus (CMV) infection
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)
Maribavir is part of a new class of anti-cytomegalovirus (CMV) , benzimidazole ribosides, that inhibit viral DNA assembly and inhibits egress of viral capsids from the nucleus of infected cells. Maribavir is active in vitro against strains of CMV that are resistant to commonly used anti-CMV drugs. [ViroPharma] Maribavir inhibits the human CMV UL97 viral protein kinase which prevents the virus from encapsulating and leaving infected cells.
1263W94
Maribavir Use and Manufacturing
Treatment of cytomegalovirus infections (antiviral).
Human drugs -> Rare disease (orphan)|Human Drugs -> EU pediatric investigation plans
Computed Properties
Molecular Weight:376.2
XLogP3:2.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:375.0752615
Monoisotopic Mass:375.0752615
Topological Polar Surface Area:99.8
Heavy Atom Count:24
Complexity:447
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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