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Bepridil hydrochloride

Bepridil hydrochloride structure

CAS No:
68099-86-5
Formula:
C24H34N2O.ClH
Chemical Name:
Bepridil hydrochloride
Synonyms:
1-Pyrrolidineethanamine,β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-,hydrochloride (1:1);1-Pyrrolidineethanamine,β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-,monohydrochloride;1978CERM;Bepridil hydrochloride;Cordium;Vascor;Bepricor;49571-05-3
Categories:
Specialty Chemicals

Description

Bepridil hydrochloride (CERM 1978) is a calcium channel blocker, with antianginal activity.

A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.

Bepridil hydrochloride Basic Attributes

Molecular Weight：

403

Exact Mass：

402.24400

EC Number：

268-472-2

NSC Number：

758390

DSSTox ID：

DTXSID5040176

Characteristics

PSA：

15.7

Appearance：

white powder

Density：

1.054g/cm3

Flash Point：

133.2ºC

Collision Cross Section：

191.4 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

wgk germany：

RTECS Number：

UY1162000

Precautionary statement(s)：

P261, P271, P272, P280, P285, P302+P352, P304+P312, P304+P340, P304+P341, P312, P321, P333+P313, P342+P311, P363, P501

Hazard Statements：

H317

Drug Information

MeSH：

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

1978 CERM

Bepridil hydrochloride Use and Manufacturing

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:403.0
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:10
Exact Mass:402.2437914
Monoisotopic Mass:402.2437914
Topological Polar Surface Area:15.7
Heavy Atom Count:28
Complexity:382
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Bepridil hydrochloride

Unit Price: $1352.95 /G FOB

CAS No.: 68099-86-5

Content: 98%

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