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BAFILOMYCIN C1

BAFILOMYCIN C1 structure

CAS No:
88979-61-7
Formula:
C39H60O12
Chemical Name:
BAFILOMYCIN C1
Synonyms:
BAFILOMYCIN C1;2-Demethyl-2-methoxy-24-methylhygrolidin;Antibiotic L-681110A1;L-681110A1
Categories:
Organic Chemistry > Lactones

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BAFILOMYCIN C1 Basic Attributes

Molecular Weight：

720.89

Exact Mass：

720.408477

Characteristics

PSA：

178

XLogP3：

4.88440

Appearance：

Light tan solid

Density：

1.18 g/cm3

Boiling Point：

844.4ºC at 760 mmHg

Flash Point：

248.9ºC

Refractive Index：

1.544

Drug Information

MeSH Entry Terms：

bafilomycin C1

BAFILOMYCIN C1 Use and Manufacturing

Bafilomycin C1 is a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases). It blocks these pumps in mammalian, plant, or fungal cells, preventing proton transport and compartment acidification. Bafilomycin C1 has been shown to have angiostatic activity in the chick chorioallantoic membrane assay. It has also been used, when coupled to cellulose, to purify V-ATPases.[Cayman Chemical]

Computed Properties

Molecular Weight:720.9
XLogP3:6.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:11
Exact Mass:720.40847734
Monoisotopic Mass:720.40847734
Topological Polar Surface Area:178
Heavy Atom Count:51
Complexity:1350
Defined Atom Stereocenter Count:11
Undefined Atom Stereocenter Count:1
Defined Bond Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes