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Bafilomycin B1

Bafilomycin B1 structure

CAS No:
88899-56-3
Formula:
C44H65NO13
Chemical Name:
Bafilomycin B1
Synonyms:
2-Butenoic acid,4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-,(2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H-pyran-4-yl ester,(2E)-;Hygrolidin,37-decarboxy-2-demethyl-37-[[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]carbonyl]-2-methoxy-24-methyl-;Oxacyclohexadecane,hygrolidin deriv.;Bafilomycin B1;Setamycin;2-Butenoic acid,4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-,tetrahydro-2-hydroxy-2-[2-hydroxy-3-(10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl)-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H-pyran-4-yl ester,[2R-[2R*[1S*[2R*,4R*(E),5S*,6R*],2R*,3S*],3S*,4E,6E,9S*,10S*,11R*,12E,14Z]]-;80112-34-1
Categories:
Active Pharmaceutical Ingredients > Synthetic Anti-infective Drugs

Description

Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K+-dependent ATPase of E. coli[1].

Bafilomycin B1 Basic Attributes

Molecular Weight：

815.99

Exact Mass：

815.99

Characteristics

PSA：

207.38000

XLogP3：

3.06

Appearance：

faint yellow to yellow

Density：

1.2±0.1 g/cm3

Boiling Point：

939.4±65.0 °C at 760 mmHg

Flash Point：

521.9±34.3 °C

Refractive Index：

1.563

Storage Conditions：

−20°C

Safety Information

Hazard category：

Transport codes：

UN 3462 6.1/PG 1

wgk germany：

hazard class code：

26/27/28

safety instructions：

36/37/39-45

RTECS Number：

NG8841000

Marks：

T+

Precautionary statement(s)：

P260-P264-P280-P284-P301 + P310-P302 + P350

Hazard Statements：

H300 + H310 + H330

Bafilomycin B1 Use and Manufacturing

Bafilomycin B1 is a member of a potent family of macrocyclic lactones.Bafilomycin B1 shares the same mode of action and activity as its more accessible A1 analogue. Bafilomycin B1 is broadly active against bacteria, fungi, insects, nematodes and protozoans. Bafilomycin B1 has attracted interest as a potential agent for treating osteoporosis.