 Home > Encyclopedia > Balicatib

Balicatib

Balicatib structure

CAS No:
354813-19-7
Formula:
C23H33N5O2
Chemical Name:
Balicatib
Synonyms:
Balicatib;Balicatib, AAE-581;BalicatibN-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamide;N-[1-(Cyanomethylcarbamoyl)cyclohexyl]-4-(4-propylpiperazin-1-yl)benzamideBalicatib(AAE-581);Balicatib, >=98%;AAE-581
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Balicatib(AAE-581) is a potent and selective inhibitor of cathepsin K; 10-100 fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S.IC50 value:Target: cathepsin KThe cathepsin K inhibitor AAE-581 (balicatib) as the most advanced of them passed Phase II clinical trials in 2005. Eighty adult female Macaca fascicularis underwent bilateral ovariectomies and were dosed twice daily by oral gavage with balicatib at 0, 3, 10, and 50 mg/kg for 18 months (groups

Balicatib has been used in trials studying the treatment of Osteoporosis and Knee Osteoarthritis.

Balicatib Basic Attributes

Molecular Weight：

411.55

Exact Mass：

411.263428

UNII：

E00MVC7O57

DSSTox ID：

DTXSID10188989

HScode：

2933599090

Characteristics

PSA：

88.5

XLogP3：

2.8

Appearance：

white to off-white solid powder

Density：

1.2±0.1 g/cm3

Flash Point：

369.5±31.5 °C

Refractive Index：

1.590

Drug Information

MeSH Entry Terms：

balicatib

Computed Properties

Molecular Weight:411.5
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:411.26342531
Monoisotopic Mass:411.26342531
Topological Polar Surface Area:88.5
Heavy Atom Count:30
Complexity:621
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Balicatib

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Balicatib

CAS No.: 354813-19-7

Content: 99.00%

Inquiry