BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO

A 1.6 M solution of butyl lithium in hexane (114 mL, 182 mmol) is added to a -78° C. solution of 1, 5-dibromo-2, 4-difluorobenzene (41.3 g, 152 mmol) in diethyl ether (290 mL). Dimethylformamide (14.4 g, 198 mmol) is added and the reaction is stirred at -78° C. for 15 minutes. The reaction is quenched with 1 N HCl (300 mL), is diluted with water, and extracted three times with ethyl acetate. The organic layer is dried over sodium sulfate and the solvent is removed under reduced pressure to give crude material that is purified by silica gel chromatography with a linear gradient of 0percent to 50percent CHPreparation 145-bromo-2, 4-difluorobenzaldehydeTo a solution of l, 5-dibromo-2, 4-difluorobenzene (17.5 g, 64.2 mmol) in ether (100 mL) at -78 °C was added n-BuLi (2.5 M solution, 30.8 mL, 77 mmol) over a period of 5 min, and the reaction mixture was stirred at -78 °C for 30 min. Then DMF (9.94 mL, 148 mmol) was added in one portion, and the mixture was stirred at -78 °C for 30 min. The reaction mixture was worked up with EtOAc/sat. NHPreparation 2 5-bromo-2, 4-difluorobenzaldehyde To a solution of l, 5-dibromo-2, 4-difluorobenzene (17.5 g, 64.2 mmol) in ether (100 mL) at -78 °C was added n-BuLi (2.5 M solution, 30.8 mL, 77 mmol) over a period of 5 min, and the reaction mixture was stirred at -78 °C for 30 min. Then DMF (9.94 mL, 148 mmol) was added in one portion, and the mixture was stirred at -78 °C for 30 min. The reaction mixture was worked up with EtOAc/sat. NHTo a stirred solution of

Molecular Weight:221.00
XLogP3:2.3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:219.93353
Monoisotopic Mass:219.93353
Topological Polar Surface Area:17.1
Heavy Atom Count:11
Complexity:153
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes