BIX02189
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BIX02189
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CAS No:
1265916-41-3
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Formula:
C27H28N4O2
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Chemical Name:
BIX02189
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Synonyms:
BIX 02189;BIX-02189;BIX02189;1094614-85-3;1265916-41-3;(Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-carboxamide;BIX-02189(Random Configuration)
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CAS No:
BIX02189 Use and Manufacturing
This selective MEK/ERK pathway inhibitor (FW = 440.54 g/mol; CAS 1265916-41-3; Solubility: 100 mM in DMSO; 100 mM for monohydrochloride salt), also named (3Z)-3-[[[3-[(dimethylamino) methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo- 1H-indole-6-carboxamide, targets Mitogen/Extracellular signal-regulated Kinase-5, or MEK5 (IC50 = 1.5 nM), and Extracellular-signal-Regulated Kinase, or ERK5 (IC50 = 59 nM), showing far weaker effects on MEK1 (IC50 = 6200 nM), MEK2 (IC50 = >62
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