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2-BROMO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

2-BROMO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE structure

CAS No:
214360-62-0
Formula:
C11H15BBrNO2
Chemical Name:
2-BROMO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
Synonyms:
AKOS BRN-0197;2-BROMOPYRIDINE-5-BORONIC ACID PINACOLATE;2-BROMOPYRIDINE-5-BORONIC ACID PINACOL ESTER;2-BROMO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;2-BROMO-5-PYRIDINEBORONIC ACID PINACOL ESTER;2-BROMO-5-PYRIDYLBORONIC ACID PINACOL ESTER;RARECHEM AK ML 0446;2-Bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine
Categories:
Organic Chemistry > Coordination Complexes

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2-BROMO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Basic Attributes

Molecular Weight：

283.96

Exact Mass：

283.037903

DSSTox ID：

DTXSID00383345

HScode：

2934999090

Characteristics

PSA：

31.4

XLogP3：

2.14330

Density：

1.3±0.1 g/cm3

Boiling Point：

345.1°C at 760 mmHg

Flash Point：

162.5±23.7 °C

Refractive Index：

1.528

Safety Information

Hazard category：

IRRITANT

hazard class code：

safety instructions：

Marks：

Hazard note：

Irritant

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

2-BROMO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Use and Manufacturing

To a solution of 2-bromo-5-(4, 4, 5, 5-tetramethyl-l, 3, 2-dioxaborolan-2-yl)pyridine (3.0 g, 10.6 mmol) in CH3CN (50 mL) was added Cu(OAc)2 (1.9 g, 10.6 mmol), tert-butyl piperazine- 1- carboxylate (3.9 g, 21.2 mmol), Et3N (2.1 g, 21.1 mmol) and 4A MS (5.0 g). The reaction mixture was stirred at 80C for 16 h under N2 atmosphere. After the reaction was completed, the reaction mixture was cooled to room temperature and then filtered. The filtrate was diluted with H2O and extracted with ethyl acetate. The combined organic layer was washed with brine, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under vacuum. The residue was purified by flash column chromatography with petroleum ether/EtOAc (5/1, v/v) to afford the title compound (500 mg, 11%) as a white solid. LCMS (ESI, m/z): [M+H]+= 342.1.

Computed Properties

Molecular Weight:283.96
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:283.03792
Monoisotopic Mass:283.03792
Topological Polar Surface Area:31.4
Heavy Atom Count:16
Complexity:257
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 2-BROMO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

Hangzhou Zentra Bio-Chemical Co., Ltd. Contact Supplier

CN
2 YRS

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Trader Supplier of pharmaceutical intermediates,excipients,plant extracts,food additives,CDMO,fine cheimcals,Octadecanedioic acid,Eicosanedioic Acid

2-Bromopyridine-5-Boronic Acid Pinacol Ester 214360-62-0

CAS No.: 214360-62-0

Grade: Pharmaceutical Grade

Content: 99%

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Guide of 2-BROMO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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2-BROMO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

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