1,2-Benzisoxazol-3(2H)-one
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1,2-Benzisoxazol-3(2H)-one
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CAS No:
21725-69-9
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Formula:
C7H5NO2
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Chemical Name:
1,2-Benzisoxazol-3(2H)-one
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Synonyms:
1,2-Benzisoxazol-3(2H)-one;1,2-Benzisoxazol-3-ol;1,2-Benzisoxazolin-3-one;3-Hydroxybenzisoxazole;Benzo[d]isoxazol-3-one;3-Hydroxy-1,2-benzisoxazole;Benzo[d]isoxazol-3-ol;NSC 683715;1,2-Benzisoxazoline-3-one;1,2-Benzoxazol-3-one;2,3-Dihydro-1,2-benzoxazol-3-one;1,2-Benzoxazol-3-ol;35651-74-2
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CAS No:
Characteristics
38.3
1.1
1.4±0.1 g/cm3
145-146 °C @ Solvent: Ethanol
299.9°C at 760 mmHg
135.2±19.8 °C
1.664
0.001mmHg at 25°C
Safety Information
IRRITANT
3
36/37/38
26-36/37/39
DE4933500
Xi
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 6 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1,2-Benzisoxazol-3(2H)-one Use and Manufacturing
A solution of intermediate 1 (1, 92 M in THF) was stirred at 60°C. A solution of CDI (3, 84 M in THF) was added over 30 min. under reflux to the aforementioned solution and refluxed for another 2 hours at 60°C. The reaction mixture was cooled to 40°C and the solvent evaporated. After completion, the remaining residue was quenched with water and acidified with 12N HCI to pH 2. The mixture was stirred for 30 min. at 10- 15°C and the resulting precipitate filtrated, washed with ice-water and dried under reduced pressure at 90 °C. Quantitative Yielding 3-Hydroxybenzisoxazole (intermediate 2).Salicylhydroxamic acid 1a (77 mg, 0.5 mmol, 1 equiv) was dissolved in anhydrous THF (7 mL) under an inert (NExample 67