2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine
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![2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/788801fc3e31457ab181f5f3ad19f311.png "2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine")
2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine
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CAS No:
128249-70-7
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Formula:
C23H19N3O2
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Chemical Name:
2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine
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Synonyms:
2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine;2,6-BIS[(4R)-PHENYL-2-(OXAZOLIN-2-YL)]PYRIDINE;(R,R)-2,6-Bis(4,5-dihydro-4-phenyl-2-oxazolyl)pyridine;(R,R)-2,6-BIS(4-PHENYL-2-OXAZOLIN-2-YL)PYRIDINE;(r,r)-2,6-bis(4-phenyl-2-oxazolinyl)pyridine;(R,R)-2,2'-(2,6-PYRIDINEDIYL)BIS(4-PHENYL-2-OXAZOLINE);[R-(R,R)]-2,6-BIS(4,5-DIHYDRO-4-PHENYL-2-OXAZOLYL)PYRIDINE;(R-(R*,R*))-2,6-bis(4,5-dihydro-4-phenyl-2-oxazol
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CAS No:
2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine Basic Attributes
369.42
369.147736
555PN397NX
DTXSID10370443
29339900
Characteristics
56.1
4
white crystal
1.28±0.1 g/cm3(Predicted)
171-175 °C(lit.)
600.4±55.0 °C(Predicted)
316.9±31.5 °C
1.674
Insoluble
Refrigerator
9.72E-14mmHg at 25°C
185 º (c=1, methylene chloride)
Safety Information
NONH for all modes of transport
3
36/37/38
26-36/37/39
Xi
P261-P305 + P351 + P338
H315-H319-H335
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine Use and Manufacturing
General procedure: Cobalt(II) tetrafluoroborate hydrate (25mg, 0.0675mmol) was added to a solution of (R)-LPh (50mg, 0.135mmol) in acetonitrile (15cm3). The resultant orange solution was stirred at room temperature for one hour. The product was precipitated using an excess of diethyl ether and the precipitate was collected by vacuum filtration, leaving an orange powder. A vapour diffusion of diethyl ether into a concentrated solution of the complex in acetonitrile gave orange crystals suitable for X-ray diffraction. Yield: 0.056g, 84%.Cobalt(II) tetrafluoroborate hydrate (25mg, 0.0675mmol) was added to a solution of (R)-LPh (50mg, 0.135mmol) in acetonitrile (15cm3). The resultant orange solution was stirred at room temperature for one hour. The product was precipitated using an excess of diethyl ether and the precipitate was collected by vacuum filtration, leaving an orange powder. A vapour diffusion of diethyl ether into a concentrated solution of the complex in acetonitrile gave orange crystals suitable for X-ray diffraction. Yield: 0.056g, 84%. Elemental microanalysis: found C, 56.6; H, 3.81; N, 8.53%: calcd for C46H38B2CoF8N6O4 C, 56.9; H, 3.94; N, 8.65%. 1H NMR (CD3CN): delta 2.7 (8H, Ph H2/6), 3.0 (4H, Ph H4), 7.7 (8H, Ph H3/5), 20.0 and 36.8 (both 4H, Ox H5), 40.5 (4H, Py H3/5), 84.7 (4H, Ox H4). No peak from the Py H4 proton environment was observed, which may be obscured by the CHD2CN solvent peak.General procedure: Zinc(II)tetrafluoroborate hydrate (16mg, 0.068mmol) was added to a solution of (R)-LPh (50mg, 0.135mmol) in acetonitrile (15cm3). The resultant colourless solution was stirred at room temperature for one hour, before the product was precipitated using excess diethyl ether. The white precipitate was collected using vacuum filtration. Single crystals suitable for X-ray diffraction analysis were grown by vapour diffusion of diethyl ether into a concentrated solution of the product in acetonitrile. Yield: 0.056g, 84%.
Computed Properties
Molecular Weight:369.4
XLogP3:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:369.147726857
Monoisotopic Mass:369.147726857
Topological Polar Surface Area:56.1
Heavy Atom Count:28
Complexity:543
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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2,6-Bis[(4R)-4-phenyl-2-oxazolinyl]pyridine
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