2-broMo-5-fluoroisonicotinaldehyde

At -70°C, Slowly add n-butyllithium to a solution of diisopropylamine (24.64 g) in THF (100 mL)(2.4M) THF solution (55.5mL), During the feeding process, the temperature of the reaction system should not exceed -70°C.After the addition is complete, slowly warm up to -10°C.The temperature was again lowered to -70°C; a solution of 2-bromo-5fluoropyridine (19.48 g) in THF (100 mL) was added to the reaction system.During the feeding process, the temperature of the reaction system is maintained at -70°C and stirred for 2 hours;DMF (16.3 g) was slowly added dropwise to the reaction system.During the feeding process, the temperature of the reaction system is maintained at -70°C and stirred for 2 hours;A 4M hydrochloric acid-dioxane solution (111 mL) was slowly added dropwise to the reaction system.During the feeding process, the temperature of the reaction system should not exceed -70°C.After the addition is complete, dilute with ethyl acetate.Wash with water, Then it is washed with saturated saline solution.Separate the organic phase; dry with anhydrous sodium sulfate, filter, The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography.The title compound (20.28 g) was obtained.At 0C, To a solution of Hydroxylamine hydrochloride (2.73 g, 39.2 mmol) was added to a solution of

Molecular Weight:204.00
XLogP3:1.4
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:202.93820
Monoisotopic Mass:202.93820
Topological Polar Surface Area:30
Heavy Atom Count:10
Complexity:133
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes