6-Bromo-8-quinolinol
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6-Bromo-8-quinolinol
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CAS No:
139399-64-7
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Formula:
C9H6BrNO
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Chemical Name:
6-Bromo-8-quinolinol
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Synonyms:
8-Quinolinol,6-bromo-;6-Bromo-8-quinolinol;NSC 673454
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CAS No:
Characteristics
33.1
2.7
1.705±0.06 g/cm3(Predicted)
138-139 °C @ Solvent: Water, Ethanol
363.2±22.0 °C(Predicted)
173.5ºC
6-Bromo-8-quinolinol Use and Manufacturing
6-Bromo-8-methoxyquinoline (Intermediate 49, 59.0 g, 248 mmol) was added to 48percent HBr solution (500 ml.) under nitrogen. After stirring at 145 °C for 24 h and then cooling to RT, the reaction mixture was quenched with 2M NaOH to adjust pH to 7. The aq. phase was extracted with EtOAc (3 x 500 ml_). The combined organic phases were dried over NaK2CO3 (55.5 g, 402 mmol) was added portion wise to a mixture of 1 -(chloromethyl)-4- methoxybenzene (37.7 g, 241 mmol) and
Computed Properties
Molecular Weight:224.05
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:222.96328
Monoisotopic Mass:222.96328
Topological Polar Surface Area:33.1
Heavy Atom Count:12
Complexity:165
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
