BI-6C9
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BI-6C9
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CAS No:
791835-21-7
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Formula:
C23H25N3O4S2
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Chemical Name:
BI-6C9
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CAS No:
BI-6C9 Use and Manufacturing
BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 μM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 μM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.