Phosphoric acid, beryllium salt (1:1)

104.99

104.973

MP14L7251G

1566

Crystals

83.4

White solid. MP: 100 °C (loses water) (decomposes). Soluble in water, acetic acid. /Beryllium phosphate trihydrate/

Slightly soluble in water

Intravenous-Mouse LD50: 16 mg/kg

High heat produces toxic phosphorus oxide and beryllium oxide fumes

Loses 1 H2O at 100 °C, soluble in water and acetic acid /Trihydrate/

II

6.1(a)

1566

Ventilated, low temperature and dry; stored separately from food materials in warehouse

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Acids, caustics, chlorinated hydrocarbons, oxidizers, molten lithium. /Beryllium and beryllium compounds (as Be)/

Respirator Recommendations: At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration: /Beryllium and beryllium compounds (as Be)/[Table#1098]|Respirator Recommendations: Escape: /Beryllium and beryllium compounds (as Be)/ [Table#1099]|Wear appropriate personal protective clothing to prevent skin contact. /Beryllium and beryllium compounds (as Be)/|Wear appropriate eye protection to prevent eye contact. /Beryllium and beryllium compounds (as Be)/|Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendations involving the wearing of eye protection. /Beryllium and beryllium compounds (as Be)/

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide. /Beryllium compound, NOS/|Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. /Beryllium compound, NOS/

Response to discharge: Issue warning poison, corrosive; Restrict access; Should be removed; chemical and physical treatment.

If material not involved in fire: Keep material out of water sources and sewers. /Beryllium compound, NOS/|Personnel protection: Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. ... /Beryllium compound, NOS/|The worker should wash daily at the end of each work shift, and prior to eating, drinking, smoking, etc. /Beryllium and beryllium compounds (as Be)/|Work clothing that becomes wet or significantly contaminated sould be removed and replaced. /Beryllium and beryllium compounds (as Be)/|Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises. /Beryllium and beryllium compounds (as Be)/

/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Health: TOXIC; inhalation, ingestion, or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. /Beryllium compound, NOS/|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Fire or Explosion: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. /Beryllium compound, NOS/|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Public Safety: CALL Emergency Response Telephone Number ... As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate enclosed areas. /Beryllium compound, NOS/|/GUIDE 154: SUBSTANCES - TOXIC AND/OR CORROSIVE (NON-COMBUSTIBLE)/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Beryllium compound, NOS/|For more DOT Emergency Guidelines (Complete) data for BERYLLIUM PHOSPHATE (8 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials. /Beryllium compounds, NOS/|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article. /Beryllium compound, NOS/

Eye or skin contact can cause irritation, itching, and burning. /Soluble beryllium salts/

Permissible Exposure Limit: Table Z-2 8-hr Time Weighted Avg: 2 ug/cu m. /Beryllium and beryllium compounds/|Permissible Exposure Limit: Table Z-2 Acceptable Ceiling Concentration: 5 ug/cu m. /Beryllium and beryllium compounds/|Permissible Exposure Limit: Table Z-2 Acceptable maximum peak above the acceptable ceiling concentration for an 8-hour shift. Concentration: 25 ug/cu m. Maximum Duration: 30 minutes. /Beryllium and beryllium compounds/

NIOSH considers beryllium and beryllium compounds (as Be) to be potential occupational carcinogens. /Beryllium and beryllium compounds (as Be)/|Recommended Exposure Limit: Ceiling Value: 0.0005 mg/cu m. /Beryllium and beryllium compounds (as Be)/|NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concentration.

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Beryllium compounds are included on this list. /Beryllium Compounds/

The major hazards encountered in the use and handling of beryllium phosphate stem from its toxicologic properties. Toxic primarily by inhalation and dermal contact, effects from exposure may include skin ulceration, headache, fever, fatigue, chest pain, shortness of breath, pulmonary edema, and possibly death from heart failure. The OSHA PEL and ACGIH TLV are set at a TWA of 2 ug/cu m. Engineering control of process equipment (eg, enclosure and local exhaust ventilation) should be used to prevent inhalation and skin contact with beryllium phosphate. In activities where over-exposure is possible, workers should wear a self-contained breathing apparatus. Work clothes should not be taken home. Shipping regulations and other DOT regulatory requirements should be consulted before transport. Containers should be protected from physical damage, and stored in dry areas, away from acids, caustics, and chlorinated hydrocarbons, and oxidizing materials. Access to areas where beryllium phosphate has been discharged should be restricted, and the material removed for treatment or disposal. Before implementing land disposal of waste beryllium phosphate, consult with environmental regulatory agencies for guidance.

highly toxic

After iv injection of 12.5-250 umol/kg body wt particulate beryllium phosphate ... beryllium phosphate was removed from the blood predominantly by the non-parenchymal (sinusoidal) cells & later distributed partly to parenchymal cells & partly to the spleen.|Beryllium phosphate and beryllium sulfate accumulated in both nonparenchymal and parenchymal cells of the liver after intravenous administration.|In this work, a chemical thermodynamic speciation code (MINTEQA2) has been used to model and understand the chemistry of beryllium in simulated human biological fluids such as intracellular, interstitial, and plasma fluids, a number of airway surface fluids for patients with lung conditions, saliva, sweat, urine, bile, gastric juice, and pancreatic fluid. The results show that predicted beryllium solubility and speciation vary markedly between each simulated biological fluid. Formation of beryllium hydroxide and/or phosphate was observed in most of the modeled fluids, and results support the postulation that beryllium absorption in the gastrointestinal tract may be limited by the formation of beryllium phosphate solids. It is also postulated that beryllium is potentially 13% less soluble in the airway surface fluid of a patient with asthma when compared to a "normal" case...

Carcinogens

Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Beryllium and Related Compounds/|Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Beryllium and Related Compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Beryllium and Related Compounds/

Beryllium phosphate is not known to be produced commercially.

Health Hazards -> Carcinogens