3,4-Bis(trifluoroMethyl)broMobenzene

Sodium Hydride (60% oil suspension, 5 mmol, 200 mg) is triturated with hexane and suspended in N, N-dimethylformamide (4 mL). 1, 2, 3, 9-Tetrahydro-carbazol-4-one (2.5 mmol, 462 mg) is added to the water-cooled suspension. After 5 minutes, 5-bromo-2-trifluorobenzotrifluoride (5 mmol, 0.71 g) is added. The reaction is stirred at 85 degrees Celsius for 3.5 h. The reaction mixture is allowed to cool and is extracted into ethyl acetate (200 mL) and is washed with water (50 mL). The organic phase is dried over magnesium sulfate. Filtration, followed by concentration, and silica gel chromatography affords the desired 9-(4-Bromo-2-trifluoromethyl-phenyl)-1, 2, 3, 9-tetrahydro-carbazol-4-one as a brown foam (0.74 g, 73%).

Molecular Weight:293.00
XLogP3:4.4
Hydrogen Bond Acceptor Count:6
Exact Mass:291.93223
Monoisotopic Mass:291.93223
Heavy Atom Count:15
Complexity:220
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes