1-BOC-5-chloroindole-3-boronic acid, pinacol ester
-
1-BOC-5-chloroindole-3-boronic acid, pinacol ester
structure -
-
CAS No:
1218790-30-7
-
Formula:
C19H27BClNO5
-
Chemical Name:
1-BOC-5-chloroindole-3-boronic acid, pinacol ester
-
Synonyms:
tert-Butyl 5-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate;1-Boc-5-chloroindole-3-boronic acidpinacol ester;1-BOC-5-chloroindole-3-boronic acid, pinacol ester;tert-butyl 5-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1-carboxylate;1H-Indole-1-carboxylic acid, 5-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester;CTK8B6488;DTXSID80682308;ANW-53531;AKOS015999329;ZINC169746302
-
CAS No:
1-BOC-5-chloroindole-3-boronic acid, pinacol ester Basic Attributes
396
377.15700
DTXSID80682308
2934999090
1-BOC-5-chloroindole-3-boronic acid, pinacol ester Use and Manufacturing
Pd(dppf)Cl2 (29 mg, 0.04 mmol, 3 molpercent) and tert-butyl 5-chloro-3-iodo-1H-indole-1-carboxylate 10 (500 mg, 1.32 mmol) were placed in a dry screwcapvessel with a septum. Then, dry toluene (6.5 mL) was added, and the mixture was degassed with argon (5 min). Dry triethylamine(0.7 mL) and 4, 4, 5, 5-tetramethyl-1, 3, 2-dioxaborolane(0.3 mL, 2 mmol) were successively added to the mixture, whichwas then stirred at 80 C (preheated oil bath) for 3 h (monitoredby TLC). Subsequently the mixture was cooled to room temperatureand filtered through Celite. The filtrate was concentratedand the residue was purified by flash chromatography (eluent;hexane/ethyl acetate = 10/1) to obtain 418 mg of 11 (totalyield = 84percent). Characterization was in agreement with literaturedata.33, 34 1H NMR (500 MHz, CDCl3) d 8.08 (d, J = 8.8 Hz, 1H), 8.00(s, 1H), 7.95 (d, J = 2.1 Hz, 1H), 7.26 (dd, J = 8.8, 2.1 Hz, 1H), 1.65(s, 9H), 1.38 (s, 12H).
Computed Properties
Molecular Weight:377.7
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:377.1565161
Monoisotopic Mass:377.1565161
Topological Polar Surface Area:49.7
Heavy Atom Count:26
Complexity:546
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 1-BOC-5-chloroindole-3-boronic acid, pinacol ester
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives
Learn More Other Chemicals
-
Cyclopropanecarboxylic acid, 1-formyl-2-methyl-, ethyl ester (9CI)
260261-27-6
-
Cyclopentanecarboxylic acid, 2-(hydroxyimino)-, methyl ester (9CI)
170016-09-8
-
3-Cyclopentene-1-carboxylic acid, 1-(chlorocarbonyl)-, ethyl ester (9CI)
76910-09-3
-
1,2-Benzenedicarboxylic acid, decyl isoundecyl ester Formula
96507-80-1
-
3,9-Diazaspiro[5.5]undecane-3-carboxylic acid, 9-benzoyl-, 1,1-dimethylethyl ester Formula
851322-37-7
-
1,9-Diazaspiro[5.5]undecane-9-carboxylic acid, 1-(phenylmethyl)-, 1,1-dimethylethyl ester Formula
1100748-67-1
-
2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-acetyl-, 1,1-dimethylethyl ester Structure
742067-24-9
-
1,8-Diazaspiro[5.5]undecane-8-carboxylic acid, 1-(2,2,2-trifluoroacetyl)-, 1,1-dimethylethyl ester Structure
918896-29-4
-
What is D-glycero-D-gulo-Heptonic acid, 5-amino-2,6-anhydro-5-deoxy-, methyl ester (9CI)
761345-72-6
-
What is D-Gluconic acid, 2,5-anhydro-, 1-methylethyl ester (9CI)
485812-65-5
1-BOC-5-chloroindole-3-boronic acid, pinacol ester
SDSRequest for Quotation