4-(4-Boc-1-piperazinyl)-5-broMo-7H-pyrrolo[2,3-d]pyriMidine

Intermediate 2 (5 mmol), 1-tert-butoxycarbonylpiperazine (6 mmol) and DIEA (7.5 mmol) were dissolved in 5 ml of dioxane, and microwaved at 80 °C for 2 h. The solvent was evaporated under reduced pressure, and the mixture was evaporated, evaporated, evaporated, evaporated, evaporated, Recrystallization gave Intermediate 3. White solid, the yield is 78.5percent.General procedure: To a solution of 3a-3c (3.2mmol) and N, N-diisopropylethylamine (DIEA) (4.8mmol) in DMF (3mL) was added N-Boc-piperazine (3.6mmol), the resulting mixture was heated at 110°C for 16h. The reaction mixture was poured into ice water (30mL) and extracted with ethyl acetate (3×30mL), the combined organic layers were washed with brine (2×30mL), dried over sodium sulfate, filtered and concentrated under reduced pressure. The crude residue was purified by silica gel chromatography with petroleum ether/ethylacetate (1: 3) to obtain 4a-4c.INTERMEDIATE: Tert-butyl-4-r5-bromo-7H-pyrrolor2, 3-dlpyrimidin-4- yPpiperazine- 1 -carboxylate.ChemicalF ormula C-IsHINTERMEDIATE: Tert-butyl-4-r5-bromo-7H-pyrrolor2, 3-dlpyrimidin-4- yPpiperazine- 1 -carboxylate.ChemicalF ormula C-IsH