6-Boc-2-oxo-6-aza-spiro[3.4]octane
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![6-Boc-2-oxo-6-aza-spiro[3.4]octane structure](https://file.echemi.com/fileManage/upload/canonicalSmiles/20220812/9cb215e4099b4cef9ec5f8056ebf6017.png "6-Boc-2-oxo-6-aza-spiro[3.4]octane")
6-Boc-2-oxo-6-aza-spiro[3.4]octane
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CAS No:
203661-71-6
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Formula:
C12H19NO3
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Chemical Name:
6-Boc-2-oxo-6-aza-spiro[3.4]octane
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Synonyms:
6-Boc-2-oxo-6-aza-spiro[3...;2-Oxo-6-aza-spiro[3.4]octane-6-carboxylic acid tert-butyl-ester;2-oxo-6-Azaspiro[3.4]octane-6-carboxylic acid 1,1-dimethylethyl ester;6-Azaspiro[3.4]octan-2-one,N-BOCprotected;6-N-Boc-2-oxo-6-aza-spiro[3.4]octane;6-Azaspiro[3.4]octane-6-carboxylic acid, 2-oxo-, 1,1-dimethylethyl ester;tert-Butyl 2-oxo-7-azaspiro[3.4]octane-7-carboxylate;6-Boc-2-oxo-6-aza-spiro[3.4]octane
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CAS No:
Safety Information
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
6-Boc-2-oxo-6-aza-spiro[3.4]octane Use and Manufacturing
To a solution of R-4 (35.5 g, 121 mmol) in saturated NH[0132] To a solution of 1-5 (35.5 g, 121 mmol) in saturatedNH4Cl (64.7 g, 1.21 mol) in MeOH (400 mL) is added Zn(79.1 g, 1.21 mol). The mixture is stirred at ambient temperaturefor 8 h. The mixture is treated with H20 and extractedwith EtOAc. The organic layers are washed with brine, driedwith Na2S04 , concentrated and purified by flash chromatography(Si02 , Hep to 25percent EtOAc in Hep) to afford 1-6 (19 g, 69percent).To a solution of R-4 (82.0 g, 279 mmol) and NH
6-Boc-2-oxo-6-aza-spiro[3.4]octane
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