8-Bromo-cGMP
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8-Bromo-cGMP
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CAS No:
31356-94-2
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Formula:
C10H11BrN5O7P
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Chemical Name:
8-Bromo-cGMP
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Synonyms:
Guanosine,8-bromo-,cyclic 3′,5′-(hydrogen phosphate);4H-Furo[3,2-d]-1,3,2-dioxaphosphorin,guanosine deriv.;8-Bromoguanosine 3′,5′-monophosphate;3′,5′-Cyclic 8-bromo-GMP;8-Bromo-cyclic GMP;8-Bromoguanosine cyclic 3′,5′-phosphate;8-Bromo-3′,5′-cyclic GMP;8-Bromoguanosine cyclic 3′,5′-monophosphate;8-Bromo-cGMP;8-Bromo-3′,5′-cGMP;8-Bromoguanosine 3,5′-cyclic monophosphate;50540-10-8
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CAS No:
Description
ChEBI: A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activatin PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.
8-bromo-3',5'-cyclic GMP is a 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. It has a role as a muscle relaxant and a protein kinase G agonist. It is a 3',5'-cyclic purine nucleotide and an organobromine compound. It derives from a 3',5'-cyclic GMP.
Computed Properties
Molecular Weight:424.10
XLogP3:-2.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:1
Exact Mass:422.95795
Monoisotopic Mass:422.95795
Topological Polar Surface Area:171
Heavy Atom Count:24
Complexity:651
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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