Levocetirizine dihydrochloride
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Levocetirizine dihydrochloride
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CAS No:
130018-87-0
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Formula:
C21H25ClN2O3.2ClH
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Chemical Name:
Levocetirizine dihydrochloride
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Synonyms:
Acetic acid,2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-,hydrochloride (1:2);Acetic acid,[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-,dihydrochloride,(R)-;Acetic acid,[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-,dihydrochloride;Levocetirizine dihydrochloride;Xusal;Xyzal;Xyzall;UCB 28556;(R)-Cetirizine dihydrochloride;(R)-(-)-Cetirizine hydrochloride;Allercet;Lezyncet;Allear
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CAS No:
Description
Levocetirizine dihydrochloride,(R)-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride, (Xyzal) is awhite, crystalline powder and is water soluble. ThisR-enantiomer is has a 30-fold higher affinity than the S-enantiomer,and dissociates more slowly from H1-receptors.Pharmacologically, it displays the same receptor and CNSselecitivity profile as the racemate, cetirizine,and thus the same therapeutic advantages.
Levocetirizine dihydrochloride Basic Attributes
461.81
460.108734
200-659-6
W69HSF2416
DTXSID60231691
29335990
Characteristics
53
4.62800
white or off-white crystalline powder
215-220°C
542.1°C at 760 mmHg
281.6ºC
H2O: ≥23mg/mL
room temp
D25 -12.79° (c = 1 in water)
Drug Information
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment. (See all compounds classified as Histamine H1 Antagonists, Non-Sedating.)
(2-(4-((R)-(4-chlorophenyl)phenylmethyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride
Levocetirizine dihydrochloride Use and Manufacturing
Anti Histaminic
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:425.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:424.1320481
Monoisotopic Mass:424.1320481
Topological Polar Surface Area:53
Heavy Atom Count:28
Complexity:443
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Antihistamine effect
Registered Holders
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SYMED LABS LTD
Active
United States
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Chongqing Shengkai Pharmaceutical Co., Ltd.
Active
China
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Zhejiang Qianyuan Haili Sheng Pharmaceutical Co., Ltd.
Active
China
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