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Levocetirizine dihydrochloride

Levocetirizine dihydrochloride structure

CAS No:
130018-87-0
Formula:
C21H25ClN2O3.2ClH
Chemical Name:
Levocetirizine dihydrochloride
Synonyms:
Acetic acid,2-[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-,hydrochloride (1:2);Acetic acid,[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-,dihydrochloride,(R)-;Acetic acid,[2-[4-[(R)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-,dihydrochloride;Levocetirizine dihydrochloride;Xusal;Xyzal;Xyzall;UCB 28556;(R)-Cetirizine dihydrochloride;(R)-(-)-Cetirizine hydrochloride;Allercet;Lezyncet;Allear
Categories:
Active Pharmaceutical Ingredients > Other Chemical Drugs

Description

Levocetirizine dihydrochloride,(R)-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride, (Xyzal) is awhite, crystalline powder and is water soluble. ThisR-enantiomer is has a 30-fold higher affinity than the S-enantiomer,and dissociates more slowly from H1-receptors.Pharmacologically, it displays the same receptor and CNSselecitivity profile as the racemate, cetirizine,and thus the same therapeutic advantages.

Levocetirizine dihydrochloride Basic Attributes

Molecular Weight：

461.81

Exact Mass：

460.108734

EC Number：

200-659-6

UNII：

W69HSF2416

DSSTox ID：

DTXSID60231691

HScode：

29335990

Characteristics

PSA：

XLogP3：

4.62800

Appearance：

white or off-white crystalline powder

Melting Point：

215-220°C

Boiling Point：

542.1°C at 760 mmHg

Flash Point：

281.6ºC

Water Solubility：

H2O: ≥23mg/mL

Storage Conditions：

room temp

Specific rotation：

D25 -12.79° (c = 1 in water)

Safety Information

Packing level：

Ⅲ

Transport codes：

UN 3077 9 / PGIII

wgk germany：

hazard class code：

22-50/53

safety instructions：

60-61

RTECS Number：

AG0990000

Marks：

Xn,N

Precautionary statement(s)：

P273

Hazard Statements：

H302-H400

Drug Information

MeSH：

A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment. (See all compounds classified as Histamine H1 Antagonists, Non-Sedating.)

MeSH Entry Terms：

(2-(4-((R)-(4-chlorophenyl)phenylmethyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride

Levocetirizine dihydrochloride Use and Manufacturing

Uses

Anti Histaminic

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:425.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:424.1320481
Monoisotopic Mass:424.1320481
Topological Polar Surface Area:53
Heavy Atom Count:28
Complexity:443
Defined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Antihistamine effect

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Levocetirizine Hydrochloride Tablets
Specifications	5mg*7 tablets

Levocetirizine Hydrochloride Tablets
Ingredients	The main ingredient of this product is levocetirizine hydrochloride, and its chemical name is (R)-(-)-2-[2-(4-(4-chlorophenyl)benzyl)-1-piperazinyl)ethoxy]acetic acid dihydrochloride.
Indication	There is no relevant research data on the interaction between levocetirizine and other drugs, and there has been no report on the interaction between cetirizine and other drugs.
Specifications	5mg
Manufacturer	Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Levocetirizine hydrochloride
Ingredients	Levocetirizine hydrochloride. Chemical name: R-(-)2-[2-[4-[4-(chlorophenyl)benzyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride.
Indication	There are no drug interaction studies using this product. Racemic cetirizine has no interaction with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, glipizide, and diazepam.
Specifications	API

See More Related Drugs

Registered Holders

SYMED LABS LTD

United States
Active
Chongqing Shengkai Pharmaceutical Co., Ltd.

China
Active
Zhejiang Qianyuan Haili Sheng Pharmaceutical Co., Ltd.

China
Active

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Guide of Levocetirizine dihydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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