2-BROMO-1-(METHOXYMETHOXY)-4-METHYLBENZENE

In a typical procedure, the appropriate bromophenol (11 mmol, 1.0 eq) was taken up in dry THF (20 mL) under N2 and cooled to 0 °C. DIEA (2.8 mL, 16 mmol, 1.5 eq) was added followed by dropwise addition of MOMCI (1.2 mL, 16 mmol, 1.5 eq). The reaction was allowed to stir and warm to RT over 18 h. The THF was removed and the crude material was redissolved in EtOAc and washed with 2 M NaOH and water. The organic layer was dried over Na2S04 and the crude material was purified by flash chromatography. 4a. Prepara ion of 2-bromo-l-(methoxymethoxy)-4-methylbenzene. In a typical procedure, the appropriate bromophenol (11 mmol, 1.0 eq) was taken up in dry THF (20 mL) under N2 and cooled to 0 °C. DIEA (2.8 mL, 16 mmol, 1.5 eq) was added followed by dropwise addition of MOMCI (1.2 mL, 16 mmol, 1.5 eq). The reaction was allowed to stir and warm to RT over 18 h. The THF was removed and the crude material was redissolved in EtOAc and washed with 2 M NaOH and water. The organic layer was dried over Na2S04 and the crude material was purified by flash chromatography. 4a. Prepara ion of 2-bromo-l-(methoxymethoxy)-4-methylbenzene.

Molecular Weight:231.09
XLogP3:2.9
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:229.99424
Monoisotopic Mass:229.99424
Topological Polar Surface Area:18.5
Heavy Atom Count:12
Complexity:130
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes