Calcein AM
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Calcein AM
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CAS No:
148504-34-1
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Formula:
C46H46N2O23
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Chemical Name:
Calcein AM
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Synonyms:
Glycine,N,N′-[[3′,6′-bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthene]-2′,7′-diyl]bis(methylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-,1,1′-bis[(acetyloxy)methyl] ester;Glycine,N,N′-[[3′,6′-bis(acetyloxy)-3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthene]-2′,7′-diyl]bis(methylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-,bis[(acetyloxy)methyl] ester;Spiro[isobenzofuran-1(3H),9′-[9H]xanthene],glycine deriv.;Calcein AM;Calcein acetoxymethyl ester;NSC 689290;150938-05-9
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CAS No:
Description
Calcein-AM is cell-permeable fluorescent dye used to determine the cell viability.
Calcein am is an organic heteropentacyclic compound that is calcein in which all four carboxy group hydrogens have been substituted by (acetyloxy)methoxy groups and the hyrodgens of the two hydroxy groups have been substituted by acetyl groups. It is a a non-fluorescent probe cleaved to a fluorescent probe by non-specific intracellular esterases. It has a role as a fluorochrome. It is an acetate ester, an organic heteropentacyclic compound, a gamma-lactone, an oxaspiro compound, a member of 2-benzofurans and a xanthene dye. It derives from a calcein.
Characteristics
305 Ų
3.49
Colorless powder
1.49±0.1 g/cm3(Predicted)
>250℃
982.7±65.0 °C(Predicted)
85 °C
n 20/D 1.479
DMSO: soluble10mg/mL, clear, colorless to slightly yellow
−20°C
Drug Information
Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. (See all compounds classified as Fluorescent Dyes.)
4',5'-bis(N,N-bis(carboxymethyl)aminomethyl)fluorescein acetoxymethyl ester
Calcein AM Use and Manufacturing
A non-fluorescent, membrane permeable probe that can be hydrolyzed to a fluorescent molecule
Computed Properties
Molecular Weight:994.9
XLogP3:2.9
Hydrogen Bond Acceptor Count:25
Rotatable Bond Count:32
Exact Mass:994.24913572
Monoisotopic Mass:994.24913572
Topological Polar Surface Area:305
Heavy Atom Count:71
Complexity:1810
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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