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calcium sulfate

calcium sulfate structure

CAS No:
99400-01-8
Formula:
CaO4S
Chemical Name:
calcium sulfate
Synonyms:
CALCIUM SULFATE;Calcium Sulfate Fcc;calcium sulfate for tofu;(2-Bromo-5-methoxy-59-methyl-phenyl)-methano
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Odorless, white powder or colorless, crystalline solid. [Note: May have blue, gray, or reddish tinge.]

Calcium sulfate is a grayish-white dense powder that occurs in nature in both an anhydrous form (anhydrite) and hydrated form(gypsum); it is also the byproduct of many chemical reactions. It has many industrial uses;for example, as a source of sulfur and sulfuric acid,in cements, tiles and plaster,as a soil conditioner, in paints, dyes,and polishes, and as a food additive.

ChEBI: Calcium sulfate is a calcium salt and an inorganic calcium salt.

calcium sulfate Basic Attributes

Molecular Weight：

136.14

Exact Mass：

135.914

Color/Form：

Off-White to Pale Grey

Characteristics

PSA：

88.6

XLogP3：

-0.25720

Appearance：

Calcium sulfate appears as odorless, white powder or colorless, crystalline solid. Crystals sometimes have a blue, gray or reddish tinge or can be brick red. Density: 2.96 g cm-3.

Density：

2.960 g/cm³

Melting Point：

>300°C

Boiling Point：

Decomposes

Water Solubility：

2.4g/L

Storage Conditions：

KEEP DRY. /DIHYDRATE/

Vapor Pressure：

0 mmHg (approx)

Flammability characteristics：

Noncombustible Solid

Odor：

PURE ANHYDROUS CALCIUM SULFATE IS ODORLESS

Critical Temperature & Pressure：

Hygroscopic, Room Temperature, under inert atmosphere

Safety Information

wgk germany：

WGK 1

Storage features：

Dry.

Precautionary statement(s)：

P261, P271, P304+P340, P312, P403+P233, P405, P501

Hazard Statements：

H335

calcium sulfate Use and Manufacturing

Pharmaceutic aid (tablet and capsule diluent). Calcium Sulfate is a general additive available as both calcium sul- fate anhydrous, made by the high-temperature calcining of gypsum which is then ground and separated, and calcium sulfate dihydrate, which is made by grinding and separating gypsum containing about 20% water of crystallization. calcium sulfate anhydrous contains approximately 29% calcium, and calcium sulfate dihydrate contains approximately 23% calcium. it is used, among other things, as a filler and baking powder for standardization purposes; a firming agent in canned potatoes, tomatoes, carrots, lima beans, and pep- pers; in dough as a source of calcium ions (because the absence of calcium ions causes bread dough to be soft and sticky and to pro- duce bread of poor quality); in soft-serve ice cream to produce dry- ness and stiffness; as a calcium ion source for reaction with alginates to form dessert gels; and as a calcium source for food enrichment. Calcium Sulfate is most often used as “gypsum” which is the dihydrate. In the form of b-anhydrite (the nearly anhydrous form), it is used as a desiccant. It is also used as a coagulant in products like “tofu”, which is a “bean curd”. When sold as a colorindicating variant under the name “Drierite ”, it appears blue or pink due to impregnation with cobalt chloride, which functions as a moisture indicator. In its natural state, unrefined calcium sulfate is a translucent, crystalline white rock. Many forms are known, including “Alabaster” and “Gypsum”. Selenite, Satin spar, Desert rose, and Gypsum flower are four varieties of Gypsum minerals; all four varieties are crystalline. The four “crystalline” varieties of gypsum are sometimes grouped together and called selenite. All have the same chemical formulation, CaSO4·2H2O. All varieties of gypsum are very soft minerals (hardness: 2 on Mohs scale). This is the most important identifying characteristic of gypsum.

Pharmaceutic aid (tablet and capsule diluent).

Drug Function and Efficacy

No specific pharmacological effects mentioned

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Calcium sulfate
Manufacturer	Taishan City Xinning Pharmaceutical Co., Ltd.

Yixin Ningshen Tablets
Ingredients	Total saponins from ginseng stems and leaves, Albizzia jasminoides, Schisandra chinensis, Ganoderma lucidum. Excipients include magnesium stearate, calcium sulfate, starch, pregelatinized starch, and talc.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Sugar-coated tablets weigh 0.3g each, film-coated tablets weigh 0.31g each
Manufacturer	SPH Liaoning Herbapex Pharmaceutical (Group) Co., Ltd.

Vitamin B6 tablets
Ingredients	Each tablet of this product contains 10 mg of vitamin B6. Excipients are: starch, calcium sulfate, magnesium stearate.
Indication	1. The combination of small doses of vitamin B6 (5 mg per day) and levodopa can reduce the efficacy of the latter in treating Parkinson's disease. However, if the preparation contains decarboxylase inhibitors such as carbidopa, it has no effect on levodopa. 2. Chloramphenicol, hydralazine hydrochloride, isoniazid, penicillamine and immunosuppressants including glucocorticoids, cyclophosphamide, cyclosporine and other drugs can antagonize vitamin B6 or enhance the excretion of vitamin B6 through the kidneys, and may even cause anemia or peripheral neuritis. 3. The dosage of vitamin B6 should be increased when taking estrogen, because estrogen can reduce the activity of vitamin B6 in the body. 4. If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	10mg
Manufacturer	Guangzhou Baiyunshan Guanghua Pharmaceutical Co., Ltd.

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Registered Holders

Hubei Gedian Renfu Medicinal Accessories Co., Ltd.

China
Active
Hunan Er-Kang Pharmaceutical Co., Ltd.

China
Active
Shanghai Qingping Pharmaceutical Co., Ltd.

China
Active

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