6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole
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6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole
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CAS No:
1231930-33-8
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Formula:
C11H12BrFN2
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Chemical Name:
6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole
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Synonyms:
1H-Benzimidazole,6-bromo-4-fluoro-2-methyl-1-(1-methylethyl)-;6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole;6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
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CAS No:
6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole Basic Attributes
271
271.13
807-019-0
DTXSID90719275
2933990090
6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole Use and Manufacturing
Add potassium tert-butoxide (6.9 kg) in portions to a solution of N-(4-bromo-2, 6- difluoro-phenyl)-N'-isopropyl-acetamidine (16.2 kg) in N-methyl formamide (76 kg) while maintaining the temperature at T<30°C. Heat the mixture at 70-75 °C until complete by HPLC. Cool to 20-30 °C and quench by adding into water (227 kg) then extract with methyl tert-butyl ether (37 X 4 kg). Wash the combined organic phases with brine (49 X 2 kg) and concentrate to 25-30 L, add n-hexane (64 kg) and filter the slurry to give 11 kg of the title compound. MS (ES
Computed Properties
Molecular Weight:271.13
XLogP3:3.3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:270.01679
Monoisotopic Mass:270.01679
Topological Polar Surface Area:17.8
Heavy Atom Count:15
Complexity:237
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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6-Bromo-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole
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