7-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine

A solution of 7-bromo-3, 4-dihydro-2H-l, 4-benzoxazine (600 mg, 2.80 mmol), di- tert-butyl dicarbonate (1.82 g, 8.33 mmol), and 4-dimethylaminopyridine (203 mg, 1.66 mmol) in pyridine (5 mL) was stirred for 16 h at 90 C. The resulting mixture was concentrated under vacuum. The residue was purified via column chromatography on silica gel (eluting with 1 : 10 ethyl acetate/petroleum ether) to afford tert-butyl 7-bromo-3, 4-dihydro-2H-l, 4-benzoxazine-4- carboxylate (440 mg, 50%) as a yellow solid.7-Bromo-4-(pyridin-2-yl)-3, 4-dihydro-2H-benzo[b] [1, 4]oxazine (1)

Molecular Weight:214.06
XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:212.97893
Monoisotopic Mass:212.97893
Topological Polar Surface Area:21.3
Heavy Atom Count:11
Complexity:142
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes