1-Bromo-2-difluoromethoxy-4-fluoro-benzene

itermediteExthp1eI5. ‘sulfOnamide ‘, “a) .To a solutiOn of 2-brotho-5-fludrophenol (3g. 15.7 mmol) in DMF (5 ml) was added cesium carbonate (7.7 g, 23.56 mmol, 1.5 eq) and sodium chlorodifluoroacetate(6 g, 39.26 nimol;2:5 eq) and the reaction mixture was heated at 100°C for 15 h. Thereaction mixture was then exttacted with Water and ethyl acetate (3 x 50 mI) Thecombined Organic layer was washed with water, brine and dried over sodium sulphate. The solvent was distilled off to afford the crude residue which was purified by column chromatography (60-120 silica ge110percent ethyl acetate in hexane) in 58 percent yield (2.2 g).

Molecular Weight:241.00
XLogP3:3.6
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:239.93976
Monoisotopic Mass:239.93976
Topological Polar Surface Area:9.2
Heavy Atom Count:12
Complexity:145
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes