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Bunolol hydrochloride

Bunolol hydrochloride structure

CAS No:
31969-05-8
Formula:
C17H25NO3.ClH
Chemical Name:
Bunolol hydrochloride
Synonyms:
1(2H)-Naphthalenone,5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-,hydrochloride (1:1);1(2H)-Naphthalenone,5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-,hydrochloride,(±)-;1(2H)-Naphthalenone,5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-,hydrochloride,(±)-;1(2H)-Naphthalenone,5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-,hydrochloride;Bunolol hydrochloride;W 6412A;dl-Bunolol hydrochloride;(±)-Bunolol hydrochloride;23271-61-6;27867-04-5
Categories:
Organic Chemistry > Amides

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Description

A nonselective beta-adrenoceptor antagonist used in the treatment of glaucoma.

Bunolol hydrochloride Basic Attributes

Molecular Weight：

327.84624

Exact Mass：

327.16

EC Number：

248-725-3

NSC Number：

759158

DSSTox ID：

DTXSID6020777

Characteristics

PSA：

58.6

XLogP3：

3.52630

Boiling Point：

464.4ºC at 760mmHg

Flash Point：

234.7ºC

Safety Information

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 47 companies from 3 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (See all compounds classified as Adrenergic beta-Antagonists.)|Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

MeSH Entry Terms：

Bunolol

Bunolol hydrochloride Use and Manufacturing

rac-Bunolol is a non-selective ?-adrenoceptor antagonist used as an anticonvulsant.

Computed Properties

Molecular Weight:327.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:327.1601214
Monoisotopic Mass:327.1601214
Topological Polar Surface Area:58.6
Heavy Atom Count:22
Complexity:350
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes