1-Bromo-3-chloro-2-iodobenzene
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1-Bromo-3-chloro-2-iodobenzene
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CAS No:
450412-28-9
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Formula:
C6H3BrClI
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Chemical Name:
1-Bromo-3-chloro-2-iodobenzene
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Synonyms:
Benzene,1-bromo-3-chloro-2-iodo-;1-Bromo-3-chloro-2-iodobenzene
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CAS No:
Characteristics
0
3.9
Solid
2.3±0.1 g/cm3
75-76 °C @ Solvent: Ethanol
285.9°C at 760 mmHg
126.7±21.8 °C
1.663
Safety Information
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, P501
H302
|Warning|H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1-Bromo-3-chloro-2-iodobenzene Use and Manufacturing
To a solution of diisopropylamine (76 mL, 0.4 mol) in anhydrous THF (664 mL) and n-hexane (220 mL) was added 2.5 M n-BuLi (160 mL, 0.4 mol) dropwise at -78 To a solution of diisopropylamine (76 mL, 0.4 mol) in anhydrous THF (664 mL) and n-hexane (220 mL) was added 2.5 M n-BuLi (160 mL, 0.4 mol) dropwise at -78° C. over 1 h. The mixture was stirred for 1 h at -78° C. and a solution of 1-bromo-3-chlorobenzene (76 g, 0.4 mol) in anhydrous THF (300 mL) was added dropwise at -78° C. After stirring for an additional 1 h at the same temperature, a solution of iodine (101 g, 0.4 mol) in anhydrous THF (400 mL) was added dropwise at -78° C. The temperature was raised from -78° C. to rt during 2 h. After stirring for 18 h at rt, the mixture was concentrated in vacuo to give the crude product (120 g) which was distilled under reduced pressure to give 1-bromo-3-fluoro-2-iodobenzene (115 g, 91percent). b) 6-Bromo-2-chloro-3 '-methyl-biphenylStep 1. l-bromo-3-chloro-2-iodobenzene: To a solution of diisopropylamine (76 mL, 0.4 mol) in anhydrous THF (664 mL) and n-hexane (220 mL) was added 2.5 M n-BuLi (160 mL, 0.4 mol) dropwise at -78 To a solution of diisopropylamine (76 mL, 0.4 mol) in anhydrous THF (664 niL) and n-hexane (220 mL) was added 2.5 M -BuLi (160 mL, 0.4 mol) dropwiseTo a solution of diisopropylamine (76 niL, 0.4 mol) in anhydrous THF (664 rnL) and n-hexane (220 rnL) was added 2.5 M n-BuLi (160 rnL, 0.4 mol) dropwise at -78