2-Bromo-3-methyl-5-nitropyridine
-
2-Bromo-3-methyl-5-nitropyridine
structure -
-
CAS No:
23132-21-0
-
Formula:
C6H5BrN2O2
-
Chemical Name:
2-Bromo-3-methyl-5-nitropyridine
-
Synonyms:
2-BROMO-5-NITRO-3-PICOLINE;2-BROMO-3-METHYL-5-NITROPYRIDINE;2-Hydorxy-5-Nitro-3-Picoline;2-HYDROXY-5-NITRO-3-PICOLINE (2-HYDROXY-3-METHYL-5-NITROPYRIDINE);6-Bromo-5-methyl-3-nitropyridine
- Categories:
-
CAS No:
2-Bromo-3-methyl-5-nitropyridine Basic Attributes
217.02
215.953430
1565441
-0
DTXSID10409464
2933399090
Safety Information
IRRITANT
36/37/38-21/22
26-36-36/37
Xi
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
H302
|Warning|H302 (83.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 6 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
2-Bromo-3-methyl-5-nitropyridine Use and Manufacturing
Synthesis of common intermediates from Scheme 4Step 1 : Synthesis of 2-bromo-3-(bromomethyl)-5-nitropyridine (Scheme 4, compound 27)A sample of 3-methyl-5-nitropyridin-2-ol (1.44 g, 9.34 mmol) was placed in 35 mL pressure vessel and dissolved in a mixture of toluene/DMF (10: 1 ratio; 15 mL). The vessel was capped with a septum, flushed with Argon and phosphorous tribromide (1.32 ml ., 14.0mmol) was added by syringe. The septum cap was replaced by a Teflon cap and the mixture was stirred for 20 min at 120 °C. The mixture was cooled to room temperature, neutralized with a 3M NaOH solution and extracted with toluene (3x). The combined organic phases were dried over anhydrous MgS0 and concentrated under vacuum to give 2.00 g of the desired 2-bromo-3-methyl-5- nitropyridine product as an orange solid (99percent).(1) and at -78 for 1-Boc-4- piperidine aldehyde (1.87g) solution of tetrahydrofuran (18) was added dropwise a tetrahydrofuran solution (9.6) of 1.06M methyl magnesium bromide, It was stirred at room temperature for 0.5 hour. After the reaction terminated, it cooled to room temperature, and the addition of saturated aqueous ammonium chloride solution, followed by extracting with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, the solvent was removed by distillation. Of the resulting residue at room temperature in ethyl acetate (18) was added a 4N hydrochloric acid / ethyl acetate solution (18), and stirred for 4 hours at the same temperature. After the reaction, hydrochloric acid was distilled off and the excess solvent. In addition, the obtained residue was purified by N, N- dimethylformamide (9.0) at room temperature was added (1) (1)
Computed Properties
Molecular Weight:217.02
XLogP3:2.1
Hydrogen Bond Acceptor Count:3
Exact Mass:215.95344
Monoisotopic Mass:215.95344
Topological Polar Surface Area:58.7
Heavy Atom Count:11
Complexity:159
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Recommended Suppliers of 2-Bromo-3-methyl-5-nitropyridine
-
![China]()
CN
5 YRS
Business licensedTrader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives -
![China]()
CN
5 YRS
Business licensed Certified factoryManufactory Supplier of Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst,Chemical Materials,Chem&Pharm Intermediates,Organic Intermediates,Feed Additive
Learn More Other Chemicals
-
2-Amino-6-chlorobenzoic acid methyl ester
41632-04-6
-
3-aMino-4-fluorobenzaldehyde
1005507-27-6
-
6-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine
1220219-97-5
-
2-AMino-N-ethyl-N-(4-fluoro-benzyl)-acetaMide Formula
779288-68-5
-
2-AMino-3-forMyl-4-chloropyridine Formula
884004-48-2
-
4-AMino-7-broMo-thieno[3,... Formula
1318133-32-2
-
5-(3-aMino-1-propen-1-yl)-Uridine Structure
97695-16-4
-
1,1-Dimethylethyl N-[1-(2-aminoethyl)-4-piperidinyl]carbamate Structure
259180-79-5
-
What is 2-Amino-5-chloro-4-fluoronitrobenzene
428871-64-1
-
What is 4-(4-(4-(4-aMinophenoxy)phenoxy)phenoxy)benzenaMine
13080-88-1
2-Bromo-3-methyl-5-nitropyridine
SDSRequest for Quotation